ArticleInfection and immunity1995
Lack of involvement of nitric oxide in killing of Aspergillus fumigatus conidia by pulmonary alveolar macrophages.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Modulation of Macrophage Function byFrontiers in cell and developmental biology · 2020Article
- Insights into the cellular responses to hypoxia in filamentous fungi.Current genetics · 2015Review
- TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis.PLoS neglected tropical diseases · 2013Article
- Innate immunity to Aspergillus species.Clinical microbiology reviews · 2009Review
- Aspergillus fumigatus: principles of pathogenesis and host defense.Eukaryotic cell · 2007Review
- Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.Infection and immunity · 2003Article
- Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates.Infection and immunity · 2003Article
- Early events in macrophage killing of Aspergillus fumigatus conidia: new flow cytometric viability assay.Clinical and diagnostic laboratory immunology · 2001Article
- Nitric oxide participation in the fungicidal mechanism of gamma interferon-activated murine macrophages against Paracoccidioides brasiliensis conidia.Infection and immunity · 2000Article
- Effect of peroxynitrite on dormant spores and germlings of Aspergillus fumigatus in vitro.Folia microbiologica · 2000Article
- Aspergillus fumigatus and aspergillosis.Clinical microbiology reviews · 1999Review
- Host defence to pulmonary mycosis.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 1999Article
- Th1 and Th2 cytokines in mice with invasive aspergillosis.Infection and immunity · 1997Article
- Development of an in vitro macrophage system to assess Penicillium marneffei growth and susceptibility to nitric oxide.Infection and immunity · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide is an important antimicrobial mechanism of phagocytes from mice and rats, but in the case of human phagocytes, secretion is still controversial. We investigated whether nitric oxide is involved in the killing of Aspergillus fumigatus conidia by human or murine pulmonary alveolar macrophages. Stimulation of the macrophages with gamma interferon and Escherichia coli lipopolysaccharide had no effect on fungicidal activity against conidia in vitro, with or without the addition of tetrahydrobiopterin. Killing of conidia (means +/- standard deviations) by murine or human alveolar macrophages, before and after stimulation, was 44% +/- 13% and 49% +/- 12% (P = 0.34) and 24% +/- 5% and 29% +/- 10% (P = 0.20), respectively. Fungicidal activity was unaltered in the presence of the competitive inhibitor NG-monomethyl L-arginine, and nitrite was undetectable in cell supernatants. Peritoneal macrophages from B6C3F1 mice produced 18 mumol of nitrite per 10(6) cells in 18 h. In conclusion, nitric oxide does not appear to be involved in the fungicidal activity of murine or human alveolar macrophages against A. fumigatus conidia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.