ArticleInfection and immunity1995
Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 100 citations in OpenAlex.
- From High Protection to Lethal Effect: Diverse Outcomes of Immunization Against Invasive Candidiasis with DifferentInternational journal of molecular sciences · 2024Article
- Direct synthesis, characterization,Royal Society open science · 2024Article
- Biofilm Formation and Aspartyl Proteinase Activity and Their Association with Azole Resistance AmongInfection and drug resistance · 2023Article
- The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence.Cell reports · 2021Article
- Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework.Infection and immunity · 2016Review
- Studies of Immune Responses in Candida vaginitis.Pathogens (Basel, Switzerland) · 2015Review
- Candida albicans OPI1 regulates filamentous growth and virulence in vaginal infections, but not inositol biosynthesis.PloS one · 2015Article
- The MP65 gene is required for cell wall integrity, adherence to epithelial cells and biofilm formation in Candida albicans.BMC microbiology · 2011Article
- The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity.Infection and immunity · 2010Article
- Candida albicans cell wall proteins.Microbiology and molecular biology reviews : MMBR · 2008Review
- Animal models: an important tool in mycology.Medical mycology · 2007Review
- Anticandidal immunity and vaginitis: novel opportunities for immune intervention.Infection and immunity · 2007Review
- Expression of Candida albicans secreted aspartyl proteinase in acute vaginal candidiasis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2007Article
- Candida parapsilosis characterization in an outbreak setting.Emerging infectious diseases · 2004Article
- Prevalence and exoenzyme secretion by Candida albicans isolates from oral and vaginal mucosas of HIV-infected women.Mycopathologia · 2004Article
- Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.Microbiology and molecular biology reviews : MMBR · 2003Review
- Competitive binding inhibition enzyme-linked immunosorbent assay that uses the secreted aspartyl proteinase of Candida albicans as an antigenic marker for diagnosis of disseminated candidiasis.Clinical and diagnostic laboratory immunology · 2003Article
- The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.Infection and immunity · 2003Article
- Immune cell-mediated protection against vaginal candidiasis: evidence for a major role of vaginal CD4(+) T cells and possible participation of other local lymphocyte effectors.Infection and immunity · 2002Article
- Differential activation of a Candida albicans virulence gene family during infection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Several strains of Candida albicans were compared for their ability to cause vaginal infection in a rat model, and their vaginopathic potentials were correlated with the expression of two aspartyl proteinases genes (SAP1 and SAP2) and adherence in vivo to the vaginal epithelium. Dot blot reactions and Northern blot analysis with RNA extracted from the vaginal fluid of rats infected with the highly vaginopathic strains H12 and 10261 demonstrated the expression of both SAP1 and SAP2 during the first week of infection. In contrast, neither gene was expressed during infection by a nonvaginopathic strain (N), even though the organism could be recovered during the first 24 h postinfection. A moderately vaginopathic strain (P) also expressed both genes, but the level of SAP1 mRNA appeared to decrease prior to that of SAP2. Neither gene was expressed, even by the highly vaginopathic strains, after the first week of infection, concomitant with a decrease in the number of organisms recovered from the vaginas. Analysis of in vivo adherence showed that the nonvaginopathic strain (N) adhered to vaginal epithelial cells less readily than the highly vaginopathic strain (H12) and moderately vaginopathic strain (P). Thus, in addition to its inability to express SAP1 and SAP2 in vivo, the nonvaginopathic strain does not colonize host cells to the same extent as the other strains tested. Our results demonstrate the early in vivo expression of two aspartyl proteinase gene during candidal vaginitis and suggest its association with the establishment of a vaginal infection.
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