ArticleArchives of disease in childhood1994
Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome.
Article in Archives of disease in childhood, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Nitrogen mustard therapy and nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 1996Trial
- Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome.JCI insight · 2024Article
- Trends in pediatric nephrotic syndrome.World journal of nephrology · 2021Review
- Article
- Prevalence of NPHS2 gene R229Q polymorphism in Bangladeshi children with nephrotic syndrome.Heliyon · 2020Article
- Health-related quality of life in Egyptian children with nephrotic syndrome.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Cyclosporine-A-Induced Intracranial Thrombotic Complications: Systematic Review and Cases Report.Frontiers in neurology · 2020Article
- Levamisole in Children with Idiopathic Nephrotic Syndrome: Clinical Efficacy and Pathophysiological Aspects.Journal of clinical medicine · 2019Review
- Prospects of genetic testing for steroid-resistant nephrotic syndrome in Nigerian children: a narrative review of challenges and opportunities.International journal of nephrology and renovascular disease · 2019Review
- A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome.Biomarker insights · 2017Article
- Pathogenesis of childhood idiopathic nephrotic syndrome: a paradigm shift from T-cells to podocytes.World journal of pediatrics : WJP · 2015Review
- Is rituximab effective in childhood nephrotic syndrome? Yes and no.Pediatric nephrology (Berlin, Germany) · 2014Review
- Short- and long-term efficacy of levamisole in children with steroid-sensitive nephrotic syndrome.International urology and nephrology · 2013Article
- LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile.Journal of cell communication and signaling · 2013Article
- Clinical course and NPHS2 analysis in patients with late steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2008Article
- Treatment of steroid sensitive nephrotic syndrome.Indian journal of pediatrics · 2005Review
- Long-term effects of levamisole treatment in childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2004Article
- The use of steroid-sparing agents in steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2003Article
- Cerebral sinus thrombosis in a child with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A review was undertaken of the use of alternative immunosuppressive treatment in addition to corticosteroids in a cohort of 429 children with steroid sensitive nephrotic syndrome (SSNS) treated between 1980 and 1994. Two hundred and twenty two children (52%) received at least one course of alternative treatment, 98 (23%) two, and 43 (10%) three. Cyclophosphamide was administered to 196 children (46%); in 181 it was the first course of alternative treatment and in 104 (57%) of those it was also the last ('final course'). Levamisole was given to 56 children (13%) and cyclosporin to 53 (12%). Fifteen children in whom cyclosporin failed were treated with chlorambucil. A few patients received azathioprine or vincristine. Ten children developed secondary steroid resistance, of whom five progressed to chronic renal failure. Acute complications included reversible renal failure, septicaemia, peritonitis, convulsions, and cerebral thrombosis. There were three deaths. It is concluded that half of the referred children with SSNS were deemed to require at least one course of alternative immunosuppressive treatment, and that side effects of the treatment and complications of SSNS are infrequent but occasionally fatal.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.