ArticleAntimicrobial agents and chemotherapy1995
Multidrug resistance in Candida albicans: disruption of the BENr gene.
Article in Antimicrobial agents and chemotherapy, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 90 citations in OpenAlex.
- Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence.AMB Express · 2025Article
- The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model.BMC microbiology · 2024Article
- Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters ofJournal of fungi (Basel, Switzerland) · 2021Review
- An Azole-Tolerant Endosomal Trafficking Mutant of Candida albicans Is Susceptible to Azole Treatment in a Mouse Model of Vaginal Candidiasis.Antimicrobial agents and chemotherapy · 2017Article
- Endosomal Trafficking Defects Can Induce Calcium-Dependent Azole Tolerance in Candida albicans.Antimicrobial agents and chemotherapy · 2016Article
- Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p.Scientific reports · 2015Article
- Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals.Antimicrobial agents and chemotherapy · 2015Article
- MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?Frontiers in physiology · 2014Review
- Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.The Journal of biological chemistry · 2013Article
- Candida glabrata drug:H+ antiporter CgQdr2 confers imidazole drug resistance, being activated by transcription factor CgPdr1.Antimicrobial agents and chemotherapy · 2013Article
- The dual role of candida glabrata drug:H+ antiporter CgAqr1 (ORF CAGL0J09944g) in antifungal drug and acetic acid resistance.Frontiers in microbiology · 2013Article
- Xenobiotic efflux in bacteria and fungi: a genomics update.Advances in enzymology and related areas of molecular biology · 2011Review
- Efflux in fungi: la pièce de résistance.PLoS pathogens · 2009Review
- MFS transportome of the human pathogenic yeast Candida albicans.BMC genomics · 2008Article
- Multidrug resistance in fungi.Eukaryotic cell · 2007Review
- Article
- Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site.Eukaryotic cell · 2006Article
- Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans.Antimicrobial agents and chemotherapy · 2006Article
- Drug-induced regulation of the MDR1 promoter in Candida albicans.Antimicrobial agents and chemotherapy · 2005Article
- Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The BENr gene of Candida albicans, which confers resistance on susceptible strains of Saccharomyces cerevisiae to six structurally and functionally unrelated drugs, was described recently (R. Ben-Yaacov, S. Knoller, G. Caldwell, J. M. Becker, and Y. Koltin, Antimicrob. Agents Chemother. 38:648-652, 1994). This gene bears similarity to membrane proteins encoding antibiotic resistance in prokaryotes and eukaryotes. The effect of disruption of this gene on viability and drug susceptibility was determined. The results indicate that the gene is not essential but its inactivation leads to susceptibility to three of the four drugs tested. Inactivation of this gene did not increase the susceptibility of the mutant to benomyl, suggesting that C. albicans has other mechanisms of resistance, some of which may be additional efflux pumps that confer resistance to this tubulin-destabilizing agent.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.