ArticleProceedings of the National Academy of Sciences of the United States of America1995
The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 105 citations in OpenAlex.
- The structural basis of RanGAP1 regulation and catalysis in nuclear transport.bioRxiv : the preprint server for biology · 2026Article
- Molecular pathogenesis of Japanese encephalitis and possible therapeutic strategies.Archives of virology · 2022Review
- Functional analysis of an essential Ran-binding protein gene, CpRbp1, from the chestnut blight fungus Cryphonectria parasitica using heterokaryon rescue.Scientific reports · 2020Article
- The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration.Cellular and molecular life sciences : CMLS · 2019Review
- Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals.eLife · 2019Article
- Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.Cell research · 2017Article
- RanBP1 governs spindle assembly by defining mitotic Ran-GTP production.Developmental cell · 2014Article
- Cyclophilins as modulators of viral replication.Viruses · 2013Review
- RanBPM, a scaffolding protein for gametogenesis.Current topics in developmental biology · 2013Review
- Virus-producing cells determine the host protein profiles of HIV-1 virion cores.Retrovirology · 2012Article
- RanBPM is essential for mouse spermatogenesis and oogenesis.Development (Cambridge, England) · 2011Article
- The prospects for designer single-stranded RNA-binding proteins.Nature structural & molecular biology · 2011Article
- Nucleo-cytoplasmic transport of proteins and RNA in plants.Plant cell reports · 2011Review
- RanBPM, a scaffolding protein in the immune and nervous systems.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2007Review
- Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli.Molecular and cellular biology · 2007Article
- Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling.Current genetics · 2003Review
- Article
- The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import.The Journal of cell biology · 2002Article
- The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion.The Journal of cell biology · 2002Article
- Sequence-specific resonance assignment of the second Ran-binding domain of human RanBP2.Journal of biomolecular NMR · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ran/TC4 is an essential, nuclear GTPase implicated in the initiation of DNA replication, entry into and exit from mitosis, and in nuclear RNA and protein transport through the nuclear pore complex. This diversity of functions suggests that Ran interacts with a large number of down-stream targets. Using an overlay assay, we detected a family of putative target proteins that associate with GTP-bound Ran. The sequence of only one such protein, HTF9a/RanBP1, is known. We have now cloned two additional Ran-binding proteins, allowing identification of a distinctive, highly conserved sequence motif of approximately 150 residues. This motif represents a minimal Ran-binding domain that stabilizes the GTP-bound state of Ran. The isolated domain also functions as a coactivator of Ran-GTPase-activating protein. Mutation of a conserved residue within the Ran-binding domain of HTF9a protein drastically reduced Ran binding. Ran-binding proteins coimmunoprecipitated with epitope-tagged Ran from cell lysates, suggesting that these proteins may associate in vivo. A previously uncharacterized Caenorhabditis elegans gene could encode a protein (96 kDa) possessing two Ran-binding domains. This open reading frame also contains similarities to nucleoporins, suggesting a functional link between Ran and nuclear pore complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.