ArticleThe Journal of cell biology1995
Molecular cloning of chick beta-tectorin, an extracellular matrix molecule of the inner ear.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 79 citations in OpenAlex.
- Evolutionary constraints impose multiple checkpoints that block mammalian sensory hair cell regeneration.Frontiers in cell and developmental biology · 2026Review
- Keratan sulfate, an electrosensory neurosentient bioresponsive cell instructive glycosaminoglycan.Glycobiology · 2024Review
- Visualizing Collagen Fibrils in the Cochlea's Tectorial and Basilar Membranes Using a Fluorescently Labeled Collagen-Binding Protein Fragment.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Frontiers in cell and developmental biology · 2022Article
- Zona Pellucida Genes and Proteins: Essential Players in Mammalian Oogenesis and Fertility.Genes · 2021Review
- Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics.Cell reports · 2021Article
- The Tectorial Membrane: Mechanical Properties and Functions.Cold Spring Harbor perspectives in medicine · 2019Review
- The TECTA mutation R1890C is identified as one of the causes of genetic hearing loss: a case report.BMC medical genetics · 2019Article
- Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections.Physical review letters · 2019Article
- Article
- The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss.Neural plasticity · 2018Review
- Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear.PloS one · 2014Article
- DFNA8/12 caused by TECTA mutations is the most identified subtype of nonsyndromic autosomal dominant hearing loss.Human mutation · 2011Article
- Zona pellucida domain-containing protein β-tectorin is crucial for zebrafish proper inner ear development.PloS one · 2011Article
- The cell biology of touch.The Journal of cell biology · 2010Review
- Expression, functional, and structural analysis of proteins critical for otoconia development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- A duplicated motif controls assembly of zona pellucida domain proteins.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Anatomical and molecular design of the Drosophila antenna as a flagellar auditory organ.Microscopy research and technique · 2004Review
- Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides.The Journal of clinical investigation · 2004Article
- Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.The Journal of biological chemistry · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tectorial membrane is an extracellular matrix lying over the apical surface of the auditory epithelium. Immunofluorescence studies have suggested that some proteins of the avian tectorial membrane, the tectorins, may be unique to the inner ear (Killick, R., C. Malenczak, and G. P. Richardson. 1992. Hearing Res. 64:21-38). The cDNA and deduced amino acid sequences for chick beta-tectorin are presented. The cDNA encodes a protein of 36,902.6 D with a putative signal sequence, four potential N-glycosylation sites, 13 cysteines, and a hydrophobic COOH terminus. Western blots of two-dimensional gels using antibodies to a synthetic peptide confirm the identity of the cDNA. Southern and Northern analysis suggests that beta-tectorin is a single-copy gene only expressed in the inner ear. The predicted COOH terminus is similar to that of glycosylphosphatidylinositol-linked proteins, and antisera raised to this region react with in vitro translation products of the cDNA clone but not with mature beta-tectorin. These data suggest beta-tectorin is synthesized as a glycosylphosphatidyl-inositol-linked precursor, targeted to the apical surface of the sensory epithelium by the lipid moiety, and then further processed. Sequence analysis indicates the predicted protein possesses a zona pellucida domain, a sequence that is common to a limited number of other matrix-forming proteins and may be involved in the formation of filaments. In the cochlear duct, beta-tectorin is expressed in the basilar papilla, in the clear cells and the cuboidal cells, as well as in the striolar region of the lagena macula. The expression of beta-tectorin is associated with hair cells that have an apical cell surface specialization known as the 275-kD hair cell antigen restricted to the basal region of the hair bundle, suggesting that matrices containing beta-tectorin are required to drive this hair cell type.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.