ReviewEuropean journal of pediatrics1995
Bacterial meningitis: mechanisms of disease and therapy.
Review in European journal of pediatrics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- [Health-related quality of life in children with spina bifida].Der Urologe. Ausg. A · 2006Article
- Prevention and cure of systemic Escherichia coli K1 infection by modification of the bacterial phenotype.Antimicrobial agents and chemotherapy · 2004Article
- Interaction of Neisseria meningitidis with human dendritic cells.Infection and immunity · 2001Article
- Hypothermia attenuates beta1 integrin expression on extravasated neutrophils in an animal model of meningitis.Inflammation · 2001Article
- Integrin expression on neutrophils in a rabbit model of Group B Streptococcal meningitis.Inflammation · 2000Article
- Immunoglobulin A1 protease, an exoenzyme of pathogenic Neisseriae, is a potent inducer of proinflammatory cytokines.The Journal of experimental medicine · 1999Article
- Molecular basis of virulence.Archives of disease in childhood · 1998Article
- Intrathecal production of interleukin-12 and gamma interferon in patients with bacterial meningitis.Infection and immunity · 1997Article
- Cerebrospinal fluid soluble L-selectin (sCD62L) in meningoencephalitis.Archives of disease in childhood · 1996Article
- Current concepts of bacterial meningitis.European journal of pediatrics · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial meningitis continues to be a serious infectious disease with a high morbidity and mortality in young children. Early recognition and initiation of adequate treatment are the major determinants for a good outcome. Recent advances in our understanding of the host inflammatory response by cytokines may result in the use of new therapeutic strategies. Such modulation of the inflammatory response may reduce the incidence of sequelae and death. The use of steroids as adjunctive therapy in children with bacterial meningitis probably has beneficial effects although the available data are still controversial. Additionally, studies in experimental meningitis models indicate that non-steroidal anti-inflammatory drugs and monoclonal antibodies against bacterial products, cytokines and CD18 on leucocytes reduce the extent of the meningeal inflammation. Human studies to evaluate the efficacy of these immune modulators are expected to start soon. However, prevention of bacterial meningitis by conjugate vaccines against Streptococcus pneumoniae and Neisseria meningitidis will be the most promising development in the next decade.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.