ArticleThe EMBO journal1995
Three protein binding sites form an enhancer that regulates sex- and fat body-specific transcription of Drosophila yolk protein genes.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Doublesex and GATAβ4 synergistically regulate the sex-dimorphic expression of storage protein 1 in Bombyx mori.PLoS genetics · 2025Article
- Transcriptomic comparison analysis across seven developmental stages of the Triatoma rubrofasciata, a vector of Chagas disease.BMC genomics · 2025Article
- Female semiochemicals stimulate male courtship but dampen female sexual receptivity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A genetic strategy to measure insulin signaling regulation and physiology in Drosophila.PLoS genetics · 2023Article
- Coupling high-throughput mapping with proteomics analysis delineates cis-regulatory elements at high resolution.Nucleic acids research · 2022Article
- Asymmetric interactions between doublesex and tissue- and sex-specific target genes mediate sexual dimorphism in beetles.Nature communications · 2017Article
- The role of the transformer gene in sex determination and reproduction in the tephritid fruit fly, Bactrocera dorsalis (Hendel).Genetica · 2015Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- The Wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster.BMC systems biology · 2015Article
- Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes.Insect molecular biology · 2013Article
- Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.Heredity · 2012Article
- Hormones and Sex-Specific Transcription Factors Jointly Control Yolk Protein Synthesis in Musca domestica.International journal of evolutionary biology · 2009Article
- Rapid evolution of sex pheromone-producing enzyme expression in Drosophila.PLoS biology · 2009Article
- Crystallographic analysis of a sex-specific enhancer element: sequence-dependent DNA structure, hydration, and dynamics.Journal of molecular biology · 2009Article
- Article
- Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues.PLoS genetics · 2007Article
- Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt I bY.BMC developmental biology · 2007Article
- Sex-, stage- and tissue-specific regulation by a mosquito hexamerin promoter.Insect molecular biology · 2006Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Transcription of the Drosophila yolk protein (Yp) genes is regulated by the somatic sex determination pathway. A gene at the bottom of this pathway, doublesex, encodes the female-specific DSXF and male-specific DSXM proteins that bind to and regulate transcription from several sites in the Yp genes. We report site-directed mutagenesis, protein binding and germline transformation experiments that identify and characterize the activity of a single binding site (dsxA) for the doublesex proteins and two binding sites for other regulatory proteins. A single copy of the three sites is sufficient to direct the sex and fat body specificities of Yp transcription. The sites form an enhancer with two strongly synergistic enhancer elements. One element (22 bp) consists of dsxA and an overlapping site, bzip1, that binds the DmC/EBP (slbo) protein, a member of the bZIP family of transcriptional activators. The other element is an 11 bp binding site (ref1) for an unknown protein. Tissue-specific activation requires strong cooperation between the ref1 site and the bzip1 or dsxA sites. Sex specificity is regulated exclusively by the dsxA site which connects the sex determination pathway to the target gene through DSXM repression and DSXF activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.