ArticleThe EMBO journal1995
Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 178 citations in OpenAlex.
- Differential Myf5 and Myf6 expression and muscle fiber traits in Angora, Hair, Honamlı, and Kilis goats.Tropical animal health and production · 2025Article
- Relationships Among Growth, Carcass Characteristics, andAnimals : an open access journal from MDPI · 2024Article
- Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells.Cell & bioscience · 2024Article
- Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis.Journal of muscle research and cell motility · 2024Review
- Transcriptional networks controlling stromal cell differentiation.Nature reviews. Molecular cell biology · 2021Review
- Effects of Dietary Paper MulberryAnimals : an open access journal from MDPI · 2021Article
- STAT3 Is an Upstream Regulator ofInternational journal of molecular sciences · 2021Article
- The Satellite Cell at 60: The Foundation Years.Journal of neuromuscular diseases · 2021Review
- Development and patterning of rib primordia are dependent on associated musculature.Developmental biology · 2020Article
- Chromatin Landscape During Skeletal Muscle Differentiation.Frontiers in genetics · 2020Review
- Know Your Model: How essential is that essential gene?Lab animal · 2020Article
- Induction of Skeletal Muscle Progenitors and Stem Cells from human induced Pluripotent Stem Cells.Journal of neuromuscular diseases · 2020Review
- The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network.Scientific reports · 2019Article
- Impact of local heating and cooling on skeletal muscle transcriptional response related to myogenesis and proteolysis.European journal of applied physiology · 2018Article
- The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.Seminars in cell & developmental biology · 2017Review
- Skeletal Muscle Cell Induction from Pluripotent Stem Cells.Stem cells international · 2017Review
- Zebrafish as a Model to Investigate Dynamin 2-Related Diseases.Scientific reports · 2016Article
- DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation.Stem cells international · 2016Review
- Skeletal myogenesis and Myf5 activation.Transcription · 2011Article
- Origin of vertebrate limb muscle: the role of progenitor and myoblast populations.Current topics in developmental biology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myf-6, alternatively called MRF4 or herculin, is a member of a group of muscle-specific transcription factors which also comprises Myf-5, myogenin and MyoD. All family members show distinct expression patterns during skeletal muscle development and can convert a variety of cell lines to myocytes. We disrupted the Myf-6 gene in mice to investigate its functional role in the network of regulatory factors controlling myogenesis. Homozygous mice carrying the disrupted Myf-6 gene show pronounced down-regulation of Myf-5 transcription for reasons presently unknown. Consequently, these mice represent a double knock-out model for Myf-6 and Myf-5. The mutants resemble most of the Myf-5 phenotype with aberrant and delayed early myotome formation and lack of distal rib structures. In addition, we find a reduction in the size of axial muscles in the back. Apart from changes in the pattern of some contractile protein isoforms, the existing myofibers appear fairly normal. This suggests that Myf-6 has no major role in the maturation of myotubes, as previously proposed. Our results provide evidence that skeletal myogenesis can proceed in the absence of two myogenic factors, Myf-5 and Myf-6, therefore they must exert largely non-redundant functions in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.