ArticleChromosoma1994
Analysis of centromeric activity in Robertsonian translocations: implications for a functional acrocentric hierarchy.
Article in Chromosoma, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- A working model for the formation of Robertsonian chromosomes.Journal of cell science · 2024Article
- α satellite DNA variation and function of the human centromere.Nucleus (Austin, Tex.) · 2017Article
- Centromere Destiny in Dicentric Chromosomes: New Insights from the Evolution of Human Chromosome 2 Ancestral Centromeric Region.Molecular biology and evolution · 2017Article
- The Survey of Double Robertsonian Translocation 13q; 14q in the Pedigree of 44; XX Woman: A Case Report.International journal of molecular and cellular medicine · 2017Article
- Centromere inactivation on a neo-Y fusion chromosome in threespine stickleback fish.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.Genome research · 2016Article
- Dicentric chromosomes: unique models to study centromere function and inactivation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Molecular cytogenetic characterization of a non-robertsonian dicentric chromosome 14;19 identified in a girl with short stature and amenorrhea.Case reports in genetics · 2012Article
- Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.PLoS genetics · 2010Article
- Engineered human dicentric chromosomes show centromere plasticity.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Article
- Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human population.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Article
- Article
- Chromosome stability is maintained by short intercentromeric distance in functionally dicentric human Robertsonian translocations.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1998Article
- Evidence for structural heterogeneity from molecular cytogenetic analysis of dicentric Robertsonian translocations.American journal of human genetics · 1996Article
- Molecular definition of breakpoints associated with human Xq isochromosomes: implications for mechanisms of formation.American journal of human genetics · 1996Article
- Centromere Silencing Mechanisms.Progress in molecular and subcellular biologyReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 90% of human Robertsonian translocations occur between nonhomologous acrocentric chromosomes, producing dicentric elements which are stable in meiosis and mitosis, implying that one centromere is functionally inactivated or suppressed. To determine if this suppression is random, centromeric activity in 48 human dicentric Robertsonian translocations was assigned by assessment of the primary constrictions using dual color fluorescence in situ hybridization (FISH). Preferential activity/constriction of one centromere was observed in all except three different rearrangements. The activity is meiotically stable since intrafamilial consistency of a preferentially active centromere existed in members of six families. These results support evidence for nonrandom centromeric activity in humans and, more importantly, suggest a functional hierarchy in Robertsonian translocations with the chromosome 14 centromere most often active and the chromosome 15 centromere least often active.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.