Evidence map›Paper›PMID 7719022›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society1995

Genetic map of rat chromosome 5 including the fatty (fa) locus.

G E Truett, H J Jacob, J Miller, G Drouin, N Bahary, J W Smoller, E S Lander, R L Leibel

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Molecular physiology of weight regulation in mice and humans.International journal of obesity (2005) · 2008
    Review
  2. Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1997
    Article
  3. Mapping of rat chromosome 5 markers generated from chromosome-sorted DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1997
    Article
  4. The leptin receptor gene (LEPR) maps to porcine chromosome 6.Mammalian genome : official journal of the International Mammalian Genome Society · 1997
    Article
  5. Sublocalization of the rat brown gene (B=Tyrp1) by linkage mapping.Mammalian genome : official journal of the International Mammalian Genome Society · 1996
    Article
  6. A rat homolog of the mouse deafness mutant jerker (je).Mammalian genome : official journal of the International Mammalian Genome Society · 1996
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G E TruettLaboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021.
H J Jacob
J Miller
G Drouin
N Bahary
J W Smoller
E S Lander
R L Leibel

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
THE GENOMIC BASIS OF HERITABLE OBESITY IN MICER01DK041096 · NIDDK · ROCKEFELLER UNIVERSITY · PI FRIEDMAN, JEFFREY M · 1989 to 2013
$4.9M
MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITYR01HD028047 · NICHD · ROCKEFELLER UNIVERSITY · PI LEIBEL, RUDOLPH L · 1991 to 1995
–
NICHD NIH HHS HD-28047NIDDK NIH HHS 5P30-DK-26687NIDDK NIH HHS DK-41096
6 · The paper itself

Abstract

Thirteen loci, including the obesity gene fatty (fa), were incorporated into a linkage map of rat Chromosome (Chr) 5. These loci were mapped in obese (fa/fa) progeny of a cross between BN x 13M-fal+F1 animals. Obese rats were scored for BN and 13M alleles at four loci (Ifna, D1S85h, C8b, and Lck1) by restriction fragment length polymorphisms and at eight additional loci (Glut1, Sv4j2, R251, R735, R980, R252, R371, and R1138) by simple sequence length polymorphisms (SSLP). The resulting map spans 67.3 cM of Chr5, presenting nine previously unmapped loci and one locus (Lck1) previously assigned to Chr 5 by use of somatic cell hybrid lines. Seven of the eight SSLP loci are newly identified; the SSLP linkage group alone spans 56.8 cM. The order of the loci is Sv4j2-R251-R735-R980-R1138-Ifna-fa-+ ++D1S85h-C8b-(Glut1-R252-R371)-Lck1. One locus, D1S85h, was found to lie only 0.4 cM from fa, close enough to serve as a reliable marker for the prediction of phenotype from genotype, and will be useful also for studies on the development of obesity in the fatty rat.

Indexed as

Chromosome MappingAllelesAnimalsBase SequenceGenetic LinkageMolecular Sequence DataObesityPolymorphism, GeneticRatsRats, Inbred BNRats, Zucker

Identifiers

PMID7719022

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.