ArticleAnnals of surgery1995
Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria.
Article in Annals of surgery, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 125 citations in OpenAlex.
- Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial.Annals of surgery · 2007Trial
- Preoperative Immunonutrition and Postoperative Outcomes in Radical Pancreaticoduodenectomy Patients.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- What Surgeon Should Know about Probiotics.Nutrients · 2022Article
- Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice.Journal of microbiology (Seoul, Korea) · 2020Article
- Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Changes of Intestinal Functions in Liver Cirrhosis.Inflammatory intestinal diseases · 2016Review
- Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- Effect of different supplements on eggshell quality, some characteristics of gastrointestinal tract and performance of laying hens.Veterinary research forum : an international quarterly journal · 2014Article
- Bacterial colonization and intestinal mucosal barrier development.World journal of clinical pediatrics · 2013Review
- Parenteral nutrition increases susceptibility of ileum to invasion by E coli.The Journal of surgical research · 2013Article
- Review
- Nutrition of the critically ill - emphasis on liver and pancreas.Hepatobiliary surgery and nutrition · 2012Review
- Review
- Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase.Digestive diseases and sciences · 2010Article
- Bacterial contamination of hospital-prepared enteral tube feeding formulas in Isfahan, Iran.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2009Article
- Prebiotics, probiotics, synbiotics in surgery--are they only trendy, truly effective or even dangerous?Langenbeck's archives of surgery · 2009Review
- Short-term fasting induces intra-hepatic lipid accumulation and decreases intestinal mass without reduced brush-border enzyme activity in mink (Mustela vison) small intestine.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2004Article
- Critical assessment of the methods used for detection of bacterial translocation.Pediatric surgery international · 2004Article
- The effects of lectins on indomethacin-induced small intestinal ulceration.International journal of experimental pathology · 2003Article
- Benefits and limitations of enteral nutrition in the early postoperative period.Langenbeck's archives of surgery · 2003Review
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe goal of the current study was to directly assess the role of loss of mucosal barrier function in nutritionally induced bacterial translocation.
backgroundParenteral and certain elemental enteral diets have been shown to promote bacterial translocation. The mechanisms underlying this observation, especially the question of whether nutritionally induced bacterial translocation is primarily related to loss of intestinal barrier function, versus an impaired immune system, remain to be fully elucidated.
methodsBacterial translocation was measured in vivo, ileal mucosal membranes were harvested, and their electrophysiologic properties and barrier function were measured ex vivo in the Ussing chamber system 7 days after receiving total parenteral nutrition solution parenterally (IV-TPN) or enterally (elemental diet). Chow-fed rats served as control subjects.
resultsThe incidence of bacterial translocation was significantly increased both to the mesenteric lymph nodes in vivo and across the in vitro Ussing chamber-mounted ileal mucosal membranes of the elemental diet-fed and IV-TPN-fed rats. The magnitude of Escherichia coli and phenol red transmucosal passage in the Ussing chamber was significantly higher in the IV-TPN-fed rats than in the elemental diet-fed or chow-fed animals. The potential differences across the ileal membrane were similar between the three groups at all time points. However, the specific resistances of the ileal membranes of the IV-TPN and elemental diet groups were significantly less than the chow-fed animals, indicating increased membrane permeability.
conclusionsLoss of intestinal barrier function plays a major role in nutritionally induced bacterial translocation, and the loss of mucosal barrier function to both E. coli and phenol red appeared greater in the IV-TPN than the elemental diet-fed rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.