Evidence map›Paper›PMID 7717739›Full record

Trial reportArchives of disease in childhood1995

Viable versus inactivated lactobacillus strain GG in acute rotavirus diarrhoea.

M Kaila, E Isolauri, M Saxelin, H Arvilommi, T Vesikari

Open access · bronzeAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 289 citations in OpenAlex.

  1. Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2020
    Pooled it
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  3. Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2010
    Pooled it
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M KailaUniversity of Tampere, Department of Clinical Medicine, Finland.
E Isolauri
M Saxelin
H Arvilommi
T Vesikari
Tampere University · FITampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of viable or heat inactivated human Lactobacillus casei strain GG on rotavirus immune responses in patients with rotavirus diarrhoea was assessed. Rotavirus serum IgA enzyme immunoassay antibody responses were higher in infants treated with viable L casei strain GG than in those treated with inactivated L casei strain GG. There was a significant difference at convalescence with rotavirus specific IgA secreting cells found in 10/12 infants receiving viable but only 2/13 infants receiving inactivated L casei strain GG. The results indicate that viable L casei strain GG stimulate rotavirus specific IgA antibody responses, theoretically significant in the prevention of reinfections.

Indexed as

Lacticaseibacillus caseiAcute DiseaseAntibody-Producing CellsChild, PreschoolDiarrheaEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MInfantRotavirus InfectionsImmunoglobulin AImmunoglobulin GImmunoglobulin M

Identifiers

PMID7717739
PMCPMC1510973
OpenAlexW2162095426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.