ArticleThe American journal of pathology1995
Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 95 citations in OpenAlex.
- Expression of p53, Ki-67, sox-2, oct-4, and NANOG in the tongue and trachea of Swiss mice exposed to narghile smoke.Journal of applied oral science : revista FOB · 2026Article
- The correlation between KRAS and TP53 gene mutations and early growth of pulmonary nodules.Journal of cardiothoracic surgery · 2024Article
- Increased expressions of claudin 4 and 7 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.Medical molecular morphology · 2016Article
- Correlation between histological invasiveness and the computed tomography value in pure ground-glass nodules.Surgery today · 2016Article
- One-dimensional mean computed tomography value evaluation of ground-glass opacity on high-resolution images.General thoracic and cardiovascular surgery · 2012Article
- Bronchioloalveolar neoplasia.International journal of clinical and experimental pathology · 2010Article
- Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung.Carcinogenesis · 2008Article
- Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.The American journal of pathology · 2006Article
- Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.BMC cell biology · 2002Article
- Article
- Early glandular neoplasia of the lung.Respiratory research · 2000Review
- Tumor extension and cell proliferation in adenocarcinomas of the lung.The American journal of pathology · 1999Article
- Monoclonality of atypical adenomatous hyperplasia of the lung.The American journal of pathology · 1999Article
- Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer.The American journal of pathology · 1998Article
- Analysis of p21Waf1/Cip1 expression in normal, premalignant, and malignant cells during the development of human lung adenocarcinoma.The American journal of pathology · 1997Article
- Proliferative activity and p53 protein accumulation correlate with early invasive trend, and apoptosis correlates with differentiation grade in oesophageal squamous cell carcinomas.Virchows Archiv : an international journal of pathology · 1997Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the pathogenesis of bronchioloalveolar lung carcinoma (BAC), we evaluated the lesion size, growth fraction, and p53 overexpression of atypical adenomatous hyperplasia (AAH) and early stage BAC. AAH was classified as showing low grade or high grade atypia. AAH-like carcinoma, presumably very early stage BAC, was distinguished from AAH in that it exhibited remarkable atypia suggestive of malignant potential and from overt BAC in that it lacked unequivocal malignant features, including invasive/destructive growth. The growth fraction was determined immunohistochemically in terms of the Ki-67 labeling index. The overexpression of p53 was evaluated by assessing the nuclear accumulation of immunoreactive p53 protein. Both the lesion size and the growth fraction increased from low grade AAH, to high grade AAH, to AAH-like carcinoma, and to overt adenocarcinoma. The overexpression of p53 in AAH-like carcinoma was similar to that in overt adenocarcinoma and was more frequent than that in AAH. Our findings indicate that AAH, AAH-like carcinoma, and overt BAC represent different categories, although the cellular events occurring in these lesions presumably represent a continuous spectrum of the changes that are reflected in the cytomorphology and lesion size. The findings here suggest that AAH and AAH-like carcinomas constitute a population of heterogeneous lesions representing different steps toward overt BAC.
Indexed as
Identifiers
7717455PMC1869251W1949332101What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.