ArticleAmerican journal of human genetics1995
Variability of the genetic contribution of Quebec population founders associated to some deleterious genes.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 109 citations in OpenAlex.
- Genealogical analysis as a new approach for the investigation of drug intolerance heritability.European journal of human genetics : EJHG · 2014Trial
- Association of the TNFRSF1B-rs1061622 variant with nonresponse to infliximab in ulcerative colitis.Scientific reports · 2025Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- First glance at the molecular etiology of hearing loss in French-Canadian families from Saguenay-Lac-Saint-Jean's founder population.Human genetics · 2022Article
- Article
- Allele frequency dynamics in a pedigreed natural population.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Fine mapping of genome-wide association study signals to identify genetic markers of the plasma triglyceride response to an omega-3 fatty acid supplementation.The American journal of clinical nutrition · 2019Article
- Article
- Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide.PloS one · 2010Article
- Genetic predictors of depressive symptoms in cardiac patients.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Article
- Article
- Homozygosity haplotype allows a genomewide search for the autosomal segments shared among patients.American journal of human genetics · 2007Article
- Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.American journal of human genetics · 2007Article
- The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension.Journal of human genetics · 2007Article
- Association study between the CX3CR1 gene and asthma.Genes and immunity · 2006Article
- A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3.Journal of medical genetics · 2006Article
- Autism spectrum disorders associated with X chromosome markers in French-Canadian males.Molecular psychiatry · 2006Article
- Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension.American journal of human genetics · 2005Article
- The effect of the Neolithic expansion on European molecular diversity.Proceedings. Biological sciences · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relatively high frequencies of some rare inherited disorders can be found in the Saguenay Region (Quebec). To understand this phenomenon, a research project on the 17th-century founder effect that led to the formation of French Canadians' gene pool is being carried out. The focus of this study is on founders who contributed to the Saguenay gene pool and who are related to contemporary probands suffering from any one of five hereditary diseases: cystic fibrosis, tyrosinemia, hemochromatosis, Charlevoix-Saguenay spastic ataxia, and sensorimotor polyneuropathia with or without agenesis of the corpus callosum. A control group has been added for comparison purposes. Altogether, 545 ascending genealogies have been reconstructed, using the Interuniversity Institute for Population Research's RETRO database, leading to > 2,500 founders. The genetic contribution of each founder to each group has been measured. Results show that (1) nearly 80% of the individuals' gene pool come from founders who settled in Nouvelle-France in the 17th century, whatever the group; (2) 15% of the founders explain 90% of the total genetic contribution of the founders, but this pattern varies from one group to another; (3) there is no subgroup of founders more related to any given group of individuals.
Indexed as
Identifiers
7717408PMC1801195W45915410What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.