ArticleAmerican journal of human genetics1995
Cytogenetic and molecular studies of Down syndrome individuals with leukemia.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 69 citations in OpenAlex.
- Facial Lesions as an Early Manifestation of Acute Leukemia in a Child With Down Syndrome: A Case Report.Case reports in pediatrics · 2025Article
- Cancer risk in adult congenital heart disease.International journal of cardiology. Congenital heart disease · 2023Review
- Genetic diagnosis of trisomy 21 in chimpanzees (Pan troglodytes).Primates; journal of primatology · 2020Article
- Myeloid leukemia in Down syndrome.Critical reviews in oncogenesis · 2011Review
- Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.Oncogene · 2010Article
- CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality.Journal of Zhejiang University. Science. B · 2009Article
- Is disomic homozygosity at the APECED locus the cause of increased autoimmunity in Down's syndrome?Archives of disease in childhood · 1999Article
- Trisomy 21 associated transient neonatal myeloproliferation in the absence of Down's syndrome.Archives of disease in childhood. Fetal and neonatal edition · 1998Article
- Studies of non-disjunction in trisomies 2, 7, 15, and 22: does the parental origin of trisomy influence placental morphology?Journal of medical genetics · 1998Article
- Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in Down syndrome.Genome research · 1998Article
- Isolation of a cosmid clone corresponding to an inv(21) breakpoint of a patient with transient abnormal myelopoiesis.American journal of human genetics · 1996Article
- Statistical models for trisomic phenotypes.American journal of human genetics · 1996Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
There is an increased risk of leukemia in Down syndrome (DS) patients, with estimates ranging from 14 to 30 times the incidence rate observed for chromosomally normal children. Furthermore, one type of leukemia, called "transient leukemia" (TL), occurs almost exclusively in DS infants. The basis of the association between DS and leukemia is unknown, but we and others have hypothesized that it may be influenced by the mechanism of origin of the extra chromosome. Therefore, we initiated a cytogenetic and molecular study of nondisjunction in leukemia DS individuals. To date, we have obtained blood and/or tissue samples from 55 individuals consisting of 17 cases with TL, 7 cases of acute nonlymphocytic leukemia subtype M7 (ANLL-M7, or acute megakaryoblastic leukemia, postulated to be related to TL), and 31 cases of other forms of leukemia. Analysis of these cases suggests differences between DS children with TL and those with other types of leukemia or DS individuals with no history of leukemia. Specifically, the TL and ANLL-M7 cases have a highly significant increase in the frequency of "atypical" constitutional karyotypes (i.e., mosaic trisomies, rings, and/or isochromosomes) and are almost always male. Additionally, genetic mapping studies suggest an increase in the frequency of disomic homozygosity, especially in proximal 21q, in DS individuals with TL and ANLL-M7.
Indexed as
Identifiers
7717402PMC1801215W1723965334What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.