ArticleAmerican journal of human genetics1995
Epidemiological evaluation of the use of genetics to improve the predictive value of disease risk factors.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 87 citations in OpenAlex.
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- A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits.American journal of human genetics · 2024Article
- Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas.PloS one · 2024Article
- SNP rs12982687 affects binding capacity of lncRNA UCA1 with miR-873-5p: involvement in smoking-triggered colorectal cancer progression.Cell communication and signaling : CCS · 2020Article
- The synergic effects of CTLA-4/Foxp3-related genotypes and chromosomal aberrations on the risk of recurrent spontaneous abortion among a Chinese Han population.Journal of human genetics · 2018Article
- Genome-wide gene-environment interactions on quantitative traits using family data.European journal of human genetics : EJHG · 2016Article
- Association of education & lifestyle factors with the perception of genetic knowledge on the development of lung cancer.The Indian journal of medical research · 2016Article
- Interaction of Polymorphisms of Resistin Gene Promoter -420C/G, Glutathione Peroxidase -1 Gene Pro198Leu and Cigarette Smoking in Nonalcoholic Fatty Liver Disease.Chinese medical journal · 2015Article
- Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care.Human genomics · 2012Article
- The impact of risk information exposure on women's beliefs about direct-to-consumer genetic testing for BRCA mutations.Clinical genetics · 2012Article
- Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities. Background Document to the ESHG recommendations on genetic testing and common disorders.European journal of human genetics : EJHG · 2011Review
- Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer.World journal of gastroenterology · 2010Article
- Gene-environment interaction in tobacco-related cancers.Carcinogenesis · 2008Review
- Gene-environment interactions in chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2008Article
- A model of gene-gene and gene-environment interactions and its implications for targeting environmental interventions by genotype.Theoretical biology & medical modelling · 2006Article
- High-density single nucleotide polymorphism screen in a large multiplex neural tube defect family refines linkage to loci at 7p21.1-pter and 2q33.1-q35.Birth defects research. Part A, Clinical and molecular teratology · 2006Article
- Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10.Journal of medical genetics · 2005Article
- Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer.World journal of gastroenterology · 2005Article
- Genetics and public health--evolution, or revolution?Journal of epidemiology and community health · 2004Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevention of common diseases relies on identifying risk factors and implementing intervention in high-risk groups. Nevertheless, most known risk factors have low positive predictive value (PPV) and low population-attributable fraction (PAF) for diseases (e.g., cholesterol and coronary heart disease). With advancing genetic technology, it will be possible to refine the risk-factor approach to target intervention to individuals with risk factors who also carry disease-susceptibility allele(s). We provide an epidemiological approach to assess the impact of genetic testing on the PPV and PAF associated with risk factors. Under plausible models of interaction between a risk factor and a genotype, we derive values of PPV and PAF associated with the joint effects of a risk factor and a genotype. The use of genetic testing can markedly increase the PPV of a risk factor. PPV increases with increasing genotype-risk factor interaction and increasing marginal relative risk associated with the factor, but it is inversely proportional to the prevalences of the genotype and the factor. For example, for a disease with lifetime risk of 1%, if all the risk-factor effect is confined to individuals with a susceptible genotype, a risk factor with 10% prevalence and disease relative risk of 2 in the population will have a disease PPV of 1.8%, but it will have a PPV of 91.8% among persons with a genotype of 1% prevalence. On the other hand, genetic testing and restriction of preventive measures to those susceptible may decrease the PAF of the risk factor, especially at low prevalences of the risk factor and genotype.(ABSTRACT TRUNCATED AT 250 WORDS)
Indexed as
Identifiers
7717394PMC1801200W104833818What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.