ArticleNaunyn-Schmiedeberg's archives of pharmacology1995
Two relaxation-mediating P2-purinoceptors in guinea-pig taenia caeci.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- P2-purinoceptor antagonists: III. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to suramin.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- P2-purinoceptor antagonists: I. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by small aromatic isothiocyanato-sulphonates.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Evaluation of P2-purinoceptor antagonists at two relaxation-mediating P2-purinoceptors in guinea-pig taenia coli.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- New insights on P2X purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1995Review
- Reactive red 2: a P2y-selective purinoceptor antagonist and an inhibitor of ecto-nucleotidase.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum.British journal of pharmacology · 1995Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2-Methylthio ATP, noradrenaline, adenosine 5'-O-(2-thiodiphosphate) (ADP beta S), alpha, beta-methylene ATP, ATP and adenosine caused relaxation of guinea-pig isolated taenia caeci precontracted by carbachol, with potency decreasing in the order indicated. 4,4'-Diisothiocyanatostilbene-2,2'-disulphonate (DIDS) 10, 32 and 100 microM shifted the concentration-response curve of alpha, beta-methylene ATP increasingly to the right, by the factor 141 at DIDS 100 microM. Concentration-response curves of the other agonists were not shifted to the right by DIDS 100 microM, except for the curve of ADP beta S which was shifted by the factor 2.4. The relaxation produced by 2-methylthio ATP faded rapidly. When the fade was complete, further addition of 2-methylthio ATP or ATP did not elicit relaxation, whereas the relaxant effect of alpha, beta-methylene ATP was unchanged. The results indicate that there are at least two relaxation-mediating P2-purinoceptors in guinea-pig taenia caeci, the P2Y-purinoceptor which is relatively insensitive to DIDS and a distinct receptor for alpha, beta-methylene ATP which is very sensitive to DIDS.
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Registered trials
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