ArticleMolecular & general genetics : MGG1995
The cycHJKL gene cluster plays an essential role in the biogenesis of c-type cytochromes in Bradyrhizobium japonicum.
Article in Molecular & general genetics : MGG, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed.
- Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control.Microbiology and molecular biology reviews : MMBR · 2009Review
- Mutations in cytochrome assembly and periplasmic redox pathways in Bordetella pertussis.Journal of bacteriology · 2005Article
- The roles of different regions of the CycH protein in c-type cytochrome biogenesis in Sinorhizobium meliloti.Molecular genetics and genomics : MGG · 2004Article
- Comparative genomics of Rickettsia prowazekii Madrid E and Breinl strains.Journal of bacteriology · 2004Article
- A cytochrome c from a lupanine-transforming Pseudomonas putida strain is expressed in Escherichia coli during aerobic cultivation and efficiently exported and assembled in the periplasm.Applied and environmental microbiology · 2003Article
- Features of Rhodobacter sphaeroides CcmFH.Journal of bacteriology · 2003Article
- Identification of Legionella pneumophila genes important for infection of amoebas by signature-tagged mutagenesis.Infection and immunity · 2001Article
- Interspecies complementation of Escherichia coli ccm mutants: CcmE (CycJ) from Bradyrhizobium japonicum acts as a heme chaperone during cytochrome c maturation.Journal of bacteriology · 2000Article
- Fine sequence analysis of 60 kb around the Arabidopsis thaliana AtEm1 locus on chromosome III.Plant molecular biology · 1999Article
- The active-site cysteines of the periplasmic thioredoxin-like protein CcmG of Escherichia coli are important but not essential for cytochrome c maturation in vivo.Journal of bacteriology · 1998Article
- Article
- Cell biology and molecular basis of denitrification.Microbiology and molecular biology reviews : MMBR · 1997Review
- Differential levels of specific cytochrome c biogenesis proteins in response to oxygen: analysis of the ccl operon in Rhodobacter capsulatus.Journal of bacteriology · 1997Article
- Biogenesis of respiratory cytochromes in bacteria.Microbiology and molecular biology reviews : MMBR · 1997Review
- Bacillus subtilis CcdA-defective mutants are blocked in a late step of cytochrome c biogenesis.Journal of bacteriology · 1997Article
- Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.Journal of bacteriology · 1997Article
- The role of the genes nrf EFG and ccmFH in cytochrome c biosynthesis in Escherichia coli.Molecular & general genetics : MGG · 1996Article
- Rhodobacter capsulatus CycH: a bipartite gene product with pleiotropic effects on the biogenesis of structurally different c-type cytochromes.Journal of bacteriology · 1996Article
- A chromosomal locus required for copper resistance, competitive fitness, and cytochrome c biogenesis in Pseudomonas fluorescens.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Heme synthesis in the rhizobium-legume symbiosis: a palette for bacterial and eukaryotic pigments.Journal of bacteriology · 1996Review
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3 authors.
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Abstract
We present an extended genetic analysis of the previously identified cycH locus in Bradyrhizobium japonicum. Three new open reading frames found in an operon-like structure immediately adjacent to the 3' end of cycH were termed cycJ, cycK and cycL. A deletion mutant (delta cycHJKL) and biochemical analysis of its phenotype showed that the genes of the cluster are essential for the biogenesis of cellular c-type cytochromes. Mutations in discrete regions of each of the genes were also constructed and shown to affect anaerobic respiration with nitrate and the ability to elicit an effective symbiosis with soybean, both phenotypes being a consequence of defects in cytochrome c formation. The CycK and CycL proteins share up to 53% identity in amino acid sequence with the Rhodobacter capsulatus Cc11 and Cc12 proteins, respectively, which have been shown previously to be essential for cytochrome c biogenesis, whereas cycJ codes for a novel protein of 169 amino acids with an M(r) of 17857. Localisation studies revealed that CycJ is located in the periplasmic space; it is probably anchored to the cytoplasmic membrane via an N-terminal hydrophobic domain. Based on several considerations discussed here, we suggest that the proteins encoded by the cycHJKL-cluster may be part of a cytochrome c-haem lyase complex whose active site faces the periplasm.
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