ArticleJournal of molecular evolution1995
Estimating the intensity of male-driven evolution in rodents by using X-linked and Y-linked Ube 1 genes and pseudogenes.
Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Bioinformatics and Drug Discovery.Current topics in medicinal chemistry · 2017Review
- Inferring the history of speciation in house mice from autosomal, X-linked, Y-linked and mitochondrial genes.Molecular ecology · 2008Article
- Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes.Genome research · 2008Article
- Characteristics, causes and evolutionary consequences of male-biased mutation.Proceedings. Biological sciences · 2007Review
- Mammalian male mutation bias: impacts of generation time and regional variation in substitution rates.Journal of molecular evolution · 2006Article
- Substitution rate heterogeneity and the male mutation bias.Journal of molecular evolution · 2006Article
- Male-driven evolution in closely related species of the mouse genus Mus.Journal of molecular evolution · 2005Article
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- Insertions and deletions are male biased too: a whole-genome analysis in rodents.Genome research · 2004Article
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- Discordant phylogeographic patterns between the Y chromosome and mitochondrial DNA in the house mouse: selection on the Y chromosome?Genetics · 1997Article
- Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Using sequence data from the last introns of ZFX and ZFY genes, we previously estimated the male-to-female ratio (alpha) of mutation rate to be close to 6 in higher primates and 1.8 in rodents. As the mutation rate may vary among different regions of the mammalian genome, it is interesting to see whether sequence data from other regions will give similar estimates. In this study, we have determined the partial genomic sequences of the ubiquitin-activating enzyme E1 genes (Ube 1x and Ube 1y for the X-linked and Y-linked homologues, respectively) of mice and rats and two mouse Ube 1y pseudogenes. From the intron sequences of the Ube 1 genes, we calculated the divergence of the Y-linked genes (Y = 0.161) and that of the X-linked genes (X = 0.107) between mouse and rat, and found the Y/X ratio to be 1.50. This ratio led to an estimate of alpha = 2.0 with a 95% confidence interval of (1.0, 3.9). Similar estimates of alpha were obtained if mouse Ube 1y pseudogenes were used instead of the mouse Ube 1y functional gene. These estimates are consistent with our previous estimate for rodents and suggest that the sex ratio of mutation rate in rodents is approximately only one-third of that in higher primates. Our estimate of the divergence time between Ube 1x and Ube 1y supports the view that the two genes separated before the eutherian radiation.
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