ReviewCancer metastasis reviews1994
Regulation of prostaglandin synthase-1 and prostaglandin synthase-2.
Review in Cancer metastasis reviews, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 340 citations in OpenAlex.
- Grafts in tendon repair.Materials today. Bio · 2026Review
- Article
- Age-induced prostaglandin ENature communications · 2022Article
- Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.Inflammopharmacology · 2018Article
- Ibuprofen and fatal lung cancer: A brief report of the prospective results from the Third National Health and Nutrition Examination Survey (NHANES III).Molecular and clinical oncology · 2017Article
- COX-1/PGEScientific reports · 2017Article
- Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways.Cell chemical biology · 2016Article
- Cyclooxygenase-2 polymorphisms and breast cancer associated risk in Pakistani patients.Pathology oncology research : POR · 2015Article
- Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer.Bioinformation · 2015Article
- Cyclooxygenase-2 and the inflammogenesis of breast cancer.World journal of clinical oncology · 2014Review
- Cell intrinsic role of COX-2 in pancreatic cancer development.Molecular cancer therapeutics · 2012Article
- Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors.Journal of experimental pharmacology · 2012Review
- Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway.Arthritis research & therapy · 2011Article
- Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts.PloS one · 2011Article
- Article
- Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice.Carcinogenesis · 2008Article
- Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors.BMC cancer · 2008Article
- Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis.BMC cancer · 2008Article
- Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study.International journal of biological sciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
It has been assumed that the rate-limiting step in the ligand-induced synthesis of prostaglandins is the release of arachidonic acid from membrane phospholipid stores as a result of the activation of phospholipase. The assumption has been that the arachidonic acid is converted to PGH2 by the constitutive prostaglandin synthase/cyclooxygenase EC1.14.99.1 (PGS-1) enzyme present in cells. In this model, PGS-1 is proposed to be present in excess, and the production of arachidonic acid is thought to be rate limiting. However, a second prostaglandin synthase gene, PGS-2 has recently been described. The PGS-2 gene is induced by a variety of ligands, in cells as diverse as fibroblasts, monocytes, macrophages, smooth muscle cells, ovarian granulosa cells, epithelial cells, endothelial cells, and neurons. Moreover, PGS-2 induction is inhibited in nearly all contexts by glucocorticoids. It seems likely, therefore, that the regulation of PGS-2 expression plays a critical role in the production of prostanoids, both in normal physiological processes and in pathophysiological processes involving these paracrine mediators. In this review, we consider the regulation of the two genes, PGS-1 and PGS-2, that encode the isoforms of prostaglandin synthase.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.