ArticleBritish journal of pharmacology1995
Potentiation by tumour necrosis factor-alpha of calcium signals induced by bradykinin and carbachol in human tracheal smooth muscle cells.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Modulation of airway hyperresponsiveness by rhinovirus exposure.Respiratory research · 2018Review
- TNFα enhances force generation in airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle.Biochimica et biophysica acta · 2014Article
- Fibroblasts from type 1 diabetics exhibit enhanced Ca(2+) mobilization after TNF or fat exposure.PloS one · 2014Article
- TNF-α-induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways.British journal of pharmacology · 2012Article
- Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids.The European respiratory journal · 2011Article
- TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.Journal of cellular physiology · 2010Article
- Low-level laser therapy (LLLT) attenuates RhoA mRNA expression in the rat bronchi smooth muscle exposed to tumor necrosis factor-alpha.Lasers in medical science · 2010Article
- Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13.Respiratory research · 2010Article
- Deficiency in the serum-derived hyaluronan-associated protein-hyaluronan complex enhances airway hyperresponsiveness in a murine model of asthma.International archives of allergy and immunology · 2010Article
- Physiology and pathophysiology of canonical transient receptor potential channels.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Review
- Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus.Respiratory research · 2007Article
- Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes.American journal of respiratory cell and molecular biology · 2006Article
- IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle.British journal of pharmacology · 2003Article
- TNF ligands and receptors--a matter of life and death.British journal of pharmacology · 2002Review
- Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?Respiratory research · 2000Review
- Tumour necrosis factor-alpha activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle.The Journal of physiology · 1999Article
- Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists.Thorax · 1998Review
- Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform.British journal of pharmacology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of tumour necrosis factor-alpha (TNF alpha) on the increase in cytosolic free calcium ([Ca2+])i induced by carbachol and bradykinin (BK) was investigated in human tracheal smooth muscle cells in culture (TSMC). BK (10(-12)-10(-9) M) and carbachol (10(-7)-10(-3) M) produced a concentration-dependent increase in [Ca2+]i (pD2 = 10.73 +/- 0.05 and 5.57 +/- 0.03 respectively). The increase in [Ca2+]i was significantly enhanced for both agonists in TNF alpha-treated cells (10 ng ml-1 for 24 h). However, pD2 values were not modified (10.78 +/- 0.03 and 5.62 +/- 0.04 for BK and carbachol, respectively) suggesting that no change in the apparent receptor affinity occurred. Thus, TNF alpha induced-alterations in Ca2+ homeostasis in human TSMC may be a key mechanism underlying airway hyperreactivity.
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