ArticleBritish journal of pharmacology1995
Receptors for endothelin-1 in asthmatic human peripheral lung.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 55 citations in OpenAlex.
- Endothelin.Pharmacological reviews · 2016Review
- Characterization of endothelin receptors in the peripheral lung tissues of horses unaffected and affected with recurrent airway obstruction.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2008Article
- ETB receptor polymorphism is associated with airway obstruction.BMC pulmonary medicine · 2007Article
- Suc-[Glu9,Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET(B) receptors in guinea-pig bronchus.British journal of pharmacology · 1999Article
- Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease.The American journal of pathology · 1997Article
- The effects of calcitonin gene-related peptide on tracheal smooth muscle of guinea-pigs in vitro.British journal of pharmacology · 1996Article
- The induction of a biphasic bronchospasm by the ETB agonist, IRL 1620, due to thromboxane A2 generation and endothelin-1 release in guinea-pigs.British journal of pharmacology · 1996Article
- Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon.British journal of pharmacology · 1996Article
- Humoral control of airway tone.Thorax · 1996Article
- Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin-1-induced contraction in human bronchi.British journal of pharmacology · 1996Article
- The distribution and density of receptor subtypes for endothelin-1 in peripheral lung of the rat, guinea-pig and pig.British journal of pharmacology · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
[125I]-endothelin-1 ([125I]-ET-1) binding was assessed by autoradiography in peripheral airway smooth muscle and alveolar wall tissue in human non-asthmatic and asthmatic peripheral lung. Levels of specific binding to these structures were similar in both non-asthmatic and asthmatic lung. The use of the receptor subtype-selective ligands, BQ-123 (ETA) and sarafotoxin S6c (ETB), demonstrated the existence of both ETA and ETB sites in airway smooth muscle and in alveoli. In airway smooth muscle from both sources, the great majority of sites were of the ETB subtype. Quantitative analyses of asthmatic and non-asthmatic alveolar wall tissue demonstrated that 29-32% of specific [125I]-ET-1 binding was to ETA sites and 68-71% was to ETB sites. Thus, asthma was not associated with any significant alteration in the densities of ETA and ETB receptors in peripheral human lung.
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