ArticleBritish journal of cancer1995
Loss of heterozygosity occurs at the D11S29 locus on chromosome 11q23 in invasive cervical carcinoma.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide.FEBS letters · 2007Article
- Article
- Localization of multiple melanoma tumor-suppressor genes on chromosome 11 by use of homozygosity mapping-of-deletions analysis.American journal of human genetics · 2000Article
- ei24, a p53 response gene involved in growth suppression and apoptosis.Molecular and cellular biology · 2000Article
- DNA copy number losses in human neoplasms.The American journal of pathology · 1999Review
- The molecular genetics of cervical carcinoma.British journal of cancer · 1999Review
- Article
- 11q23.1 and 11q25-qter YACs suppress tumour growth in vivo.Oncogene · 1999Article
- Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Molecular events in uterine cervical cancer.Sexually transmitted infections · 1998Review
- Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix.British journal of cancer · 1998Article
- Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis.Journal of clinical pathology · 1996Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Allelotypic detection of loss of heterozygosity (LOH) has been used to identify putative tumour-suppressor genes. Loci on human chromosome 11q23 are frequently altered in malignant disease, and LOH has been reported at an anonymous D11S29 locus at 11q23 in a proportion of breast and ovarian cancers and malignant melanomas. Previous studies have reported a high frequency of LOH in cervical carcinoma mapping to 11q23. Using polymerase chain reaction techniques employing probes for a recently described polymorphic dinucleotide microsatellite within this locus, we have searched for LOH in 69 cases of invasive cervical carcinoma. Genomic material was microdissected from sections cut from archival paraffin-embedded material, using the patients' constitutional genotype as a control Sixty-two (90%) of the cases were informative, and LOH occurred in 25/62 (40%) of tumours. Loss of an arm or single chromosome 11 is a well-recognised event in cervical carcinoma, and by employing other microsatellite polymorphisms mapping to 11q13 and 11p11-p12 we excluded those cases with widespread allelic loss. By doing so, LOH at D11S29 was found in 16/53 (30%) of tumours. The findings suggest a putative tumour-suppressor gene on 11q involved in cervical carcinogenesis.
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