ArticleBritish journal of cancer1995
Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 85 citations in OpenAlex.
- Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status.Molecular and cellular biochemistry · 2017Article
- Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.Molecular oncology · 2016Article
- Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9.Journal of natural medicines · 2011Article
- Glutathione in cancer cell death.Cancers · 2011Article
- The MRP family of drug efflux pumps.Oncogene · 2003Review
- MRP subfamily transporters and resistance to anticancer agents.Journal of bioenergetics and biomembranes · 2001Review
- ATP-dependent transport of reduced glutathione in yeast secretory vesicles.The Biochemical journal · 1998Article
- Lack of a role for MRP1 in platinum drug resistance in human ovarian cancer cell lines.British journal of cancer · 1998Article
- Molecular Events as Targets of Anticancer Drug Therapy.Pathology oncology research : POR · 1997Article
- The multidrug resistance-associated protein gene confers drug resistance in human gastric and colon cancers.Japanese journal of cancer research : Gann · 1996Article
- The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line.British journal of cancer · 1996Article
- ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The interaction of buthionine sulphoximide (BSO) and the topoisomerase I inhibitor CPT-11.The British journal of cancer. Supplement · 1996Article
- Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.Molecular aspects of medicineReview
- Hepatic glutathione and glutathione S-conjugate transport mechanisms.The Yale journal of biology and medicineReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preincubation of etoposide-resistant human MCF7 breast cancer cells (MCF7/VP) with buthionine sulphoximine (BSO) resulted in their sensitisation to etoposide and vincristine. Chemosensitisation was accompanied by elevated intracellular drug levels. In contrast, simultaneous exposure to BSO did not result in increased drug accumulation. Similar, but quantitatively smaller, effects were also observed when sensitive wild-type MCF7/WT cells were treated with BSO. In agreement with its effect on drug accumulation, BSO pretreatment also increased VP-16-stimulated cleavable complex formation between DNA topoisomerase II and cellular DNA. BSO treatment also led to a significant increase in acid-precipitable VP-16 levels in MCF7/VP, but not MCF7/WT cells. In contrast, no clear effects of BSO on drug efflux were observed and drug retention was only minimally increased after BSO treatment of both MCF7/WT and MCF7/VP cells and no difference between the two cell lines was detected. Thus, chemosensitisation by BSO appeared to be mediated through increased intracellular drug concentrations and/or protein binding.
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