ArticleProceedings of the National Academy of Sciences of the United States of America1995
Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- Infection promotes Ser-214 phosphorylation important for generation of cytotoxic tau variants.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.Physiological reviews · 2022Review
- cAMP signaling primes lung endothelial cells to activate caspase-1 duringAmerican journal of physiology. Lung cellular and molecular physiology · 2020Article
- PGEAmerican journal of physiology. Renal physiology · 2017Article
- A Facile Method to Probe the Vascular Permeability of Nanoparticles in Nanomedicine Applications.Scientific reports · 2017Article
- The Pseudomonas aeruginosa Exoenzyme Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant.Handbook of experimental pharmacology · 2017Review
- The Pseudomonas aeruginosa exoenzyme Y impairs endothelial cell proliferation and vascular repair following lung injury.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.Journal of the American Society of Nephrology : JASN · 2013Article
- Article
- Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.American journal of physiology. Cell physiology · 2012Article
- Defining the phosphodiesterase superfamily members in rat brain microvessels.ACS chemical neuroscience · 2011Article
- Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Emerging themes of cAMP regulation of the pulmonary endothelial barrier.American journal of physiology. Lung cellular and molecular physiology · 2011Review
- Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouse.American journal of physiology. Renal physiology · 2010Article
- Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells.Journal of cell science · 2010Article
- Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6.The Journal of physiology · 2009Article
- Soluble adenylyl cyclase-dependent microtubule disassembly reveals a novel mechanism of endothelial cell retraction.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- TRPing on the lung endothelium: calcium channels that regulate barrier function.Antioxidants & redox signaling · 2009Review
- The actin cytoskeleton in endothelial cell phenotypes.Microvascular research · 2009Review
- Cytosolic Ca2+ concentration and rate of increase of the cytosolic Ca2+ concentration in the regulation of vascular permeability in Rana in vivo.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Maintenance by the endothelium of a semi-permeable barrier is critically important in the exchange of oxygen and carbon dioxide in the lung. Intracellular free Ca2+ ([Ca2+]i) and cAMP are principal determinants of endothelial cell barrier function through their mutually opposing actions on endothelial retraction. However, details of the mechanisms of this antagonism are lacking. The recent discovery that certain adenylyl cyclases (EC 4.6.1.1) could be acutely inhibited by Ca2+ in the intracellular concentration range provided one possible mechanism whereby elevated [Ca2+]i could decrease cAMP content. This possibility was explored in pulmonary artery endothelial cells. The results indicate that a type VI Ca(2+)-inhibitable adenylyl cyclase exists in pulmonary artery endothelial cells and is modulated by physiological changes in [Ca2+]i. Furthermore, the results suggest the inverse relationship between [Ca2+]i and cAMP that is established by Ca(2+)-inhibitable adenylyl cyclase plays a critical role in modulating pulmonary artery endothelial cell permeability. These data provide evidence that susceptibility to inhibition of adenylyl cyclase by Ca2+ can be exploited in modulating a central physiological process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.