ArticleNucleic acids research1995
Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Understanding Amyotrophic Lateral Sclerosis: Pathophysiology, Diagnosis, and Therapeutic Advances.International journal of molecular sciences · 2024Review
- Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives.International journal of molecular sciences · 2021Review
- Amyotrophic Lateral Sclerosis Genes inInternational journal of molecular sciences · 2021Review
- Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons FromFrontiers in neuroscience · 2021Review
- RNA-protein interactions in an unstructured context.FEBS letters · 2018Review
- NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene.Scientific reports · 2018Article
- FUS toxicity is rescued by the modulation of lncRNA hsrω expression in Drosophila melanogaster.Scientific reports · 2017Article
- Role of FET proteins in neurodegenerative disorders.RNA biology · 2016Review
- FUS-linked essential tremor associated with motor dysfunction in Drosophila.Human genetics · 2016Article
- Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis.Brain research · 2016Review
- RGG boxes within the TET/FET family of RNA-binding proteins are functionally distinct.Transcription · 2016Article
- A fruitful endeavor: modeling ALS in the fruit fly.Brain research · 2015Review
- Primary paraesophageal Ewing's sarcoma: an uncommon case report and literature review.OncoTargets and therapy · 2015Article
- A genetic dichotomy between pure sclerosing epithelioid fibrosarcoma (SEF) and hybrid SEF/low-grade fibromyxoid sarcoma: a pathologic and molecular study of 18 cases.Genes, chromosomes & cancer · 2015Article
- The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage.The Journal of biological chemistry · 2013Article
- Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease.Frontiers in genetics · 2013Article
- Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS.Molecular neurodegeneration · 2012Article
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- The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.The Journal of clinical investigation · 2011Article
- Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We have previously described a partial Drosophila cDNA, clone P19, which bears homology to members of the RNA recognition motif (RRM) family of proteins [Haynes et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 1819-1823]. RNA binding as well as involvement in RNA processing has been demonstrated for some RRM proteins. We report here the further characterization of P19, which we renamed cabeza (caz). caz is located on the X chromosome at position 14B. Using Northern analysis, at least four transcripts from the caz gene were observed at varying levels during development. caz mRNA and protein are enriched in the brain and central nervous system during embryogenesis. In addition, the protein is enriched in the adult head. UV crosslinking was used to demonstrate in vitro RNA binding activity for full-length recombinant caz protein and for the caz RRM domain. Sequence analysis revealed caz is related to two human genes, EWS and TLS, which are involved in chromosomal translocations. The fusion of EWS and TLS to other cellular genes results in sarcoma formation. In addition to their overall structural organization and sequence similarity, these three genes share an RRM which is divergent from typical RRMs. Therefore, it appears that these genes constitute a new sub-family of RNA binding proteins.
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