ArticleNucleic acids research1995
DNA bending by thyroid hormone receptor: influence of half-site spacing and RXR.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Hormone response elements for the thyroid receptor-α include specific distal 5'-flanking DNA.Science advances · 2024Article
- Article
- A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver.Genes & development · 2021Article
- Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells.Endocrinology · 2016Article
- Nuclear hormone receptors in parasitic helminths.Molecular and cellular endocrinology · 2011Review
- Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites.PloS one · 2010Article
- LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Ets-1 p51 and p42 isoforms differentially modulate Stromelysin-1 promoter according to induced DNA bend orientation.Nucleic acids research · 2009Article
- Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni.BMC evolutionary biology · 2007Article
- Functional divergence between the half-sites of the DNA-binding sequence for the yeast transcriptional regulator Rap1p.The Biochemical journal · 1999Article
- Proposed mechanism for the stabilization of nuclear receptor DNA binding via protein dimerization.Molecular and cellular biology · 1997Article
- Prebending the estrogen response element destabilizes binding of the estrogen receptor DNA binding domain.Molecular and cellular biology · 1997Article
- Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitro.Nucleic acids research · 1997Article
- DNA bending by the silencer protein NeP1 is modulated by TR and RXR.Nucleic acids research · 1996Article
- A Purkinje cell protein-2 intronic thyroid hormone response element binds developmentally regulated thyroid hormone receptor-nuclear protein complexes.Journal of molecular neuroscience : MN · 1996Article
- Cross-talk between thyroid hormone and specific retinoid X receptor subtypes in yeast selectively regulates cognate ligand actions.Gene expression · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transcriptional activation by thyroid hormone (T3) requires interactions between the T3 receptor (TR) and T3 response elements (TREs) composed of two copies of sequences related to AGGTCA. Direct repeats of this sequence are a functional TRE when spaced by 4 but not by 5 bp (DR4 versus DR5). TR bound as monomers, homodimers and heterodimers with retinoid X receptor (RXR) to both DR4 and DR5, with an approximately 10-fold greater affinity for DR4 due to reduced dissociation of the protein-DNA complex. We explored DNA bending as an additional variable which could influence the transcriptional outcome of the TR-TRE interaction. Circular permutation indicated a large distortion of the DNA following TR binding, but phasing analysis strongly suggested that this was due only in small part to DNA bending. Phasing analysis indicated that both TR/RXR and TR homodimer induced bends of approximately 10 degrees in DR4, but caused little bending of DR5. Moreover, the TR homo- and heterodimers bent DR4 in opposite directions. These results indicate that in addition to regulating the affinity and spacing requirement for DNA binding by TR, the TR dimer partner may also modulate transcription by influencing the direction of the bending induced by TR binding to DNA, although this effect may be subtle, due to the modest degree of bending.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.