ArticlePflugers Archiv : European journal of physiology1994
Ca2+ channel Ca(2+)-dependent inactivation in a mammalian central neuron involves the cytoskeleton.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Stac Proteins Suppress CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Ca2+-dependent modulation of voltage-gated Ca2+ channels.Biochimica et biophysica acta · 2012Review
- Article
- Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Review
- Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures.The Journal of physiology · 2007Article
- Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat.Molecular and cellular biochemistry · 2007Article
- A biopolymer transistor: electrical amplification by microtubules.Biophysical journal · 2006Article
- Glutamate-induced Ca2+ influx in third-order neurons of salamander retina is regulated by the actin cytoskeleton.Neuroscience · 2006Article
- Cytoskeletal regulation of calcium-permeable cation channels in the human syncytiotrophoblast: role of gelsolin.The Journal of physiology · 2005Article
- Influence of Ca2+-binding proteins and the cytoskeleton on Ca2+-dependent inactivation of high-voltage activated Ca2+ currents in thalamocortical relay neurons.Pflugers Archiv : European journal of physiology · 2005Article
- Convergent regulation of skeletal muscle Ca2+ channels by dystrophin, the actin cytoskeleton, and cAMP-dependent protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors.BMC pharmacology · 2004Article
- Rac GTPase plays an essential role in exocytosis by controlling the fusion competence of release sites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Inactivation of P2X2 purinoceptors by divalent cations.The Journal of physiology · 2000Article
- Voltage- and calcium-dependent inactivation of calcium channels in Lymnaea neurons.The Journal of general physiology · 1999Article
- Microtubule cytoskeleton involvement in muscarinic suppression of voltage-gated calcium channel current in guinea-pig ileal smooth muscle.British journal of pharmacology · 1999Article
- Measurement of calcium channel inactivation is dependent upon the test pulse potential.Biophysical journal · 1999Article
- Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes.The Journal of physiology · 1999Article
- A cytoplasmic factor, calpastatin and ATP together reverse run-down of Ca2+ channel activity in guinea-pig heart.The Journal of physiology · 1999Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ca2+ channel inactivation was investigated in acutely isolated hippocampal pyramidal neurons from adult rats and found to have a component dependent on intracellular Ca2+. Ca(2+)-dependent inactivation was indentified as the additional inactivation of channel current observed when Ca2+ replaced Ba2+ as the current carrying ion, and was found to be an independent process from that of Ba2+ current inactivation based on three lines of evidence: (1) no correlation between Ca(2+)-dependent inactivation and Ba2+ current inactivation was found, (2) only Ca(2+)-dependent inactivation was reduced by intracellular application of Ca2+ chelators, and (3) only Ca(2+)-dependent inactivation was sensitive to compounds which alter the cytoskeleton. Drugs which stabilize (taxol and phalloidin) and destabilize (colchicine and cytochalasin B) the cytoskeleton altered the development and recovery from Ca(2+)-dependent inactivation, indicating that the neuronal cytoskeleton may mediate Ca2+ channel sensitivity to intracellular Ca2+. Ca(2+)-dependent inactivation was not associated with a particular subset of Ca2+ channels, suggesting that all Ca2+ channels in these neurons are inactivated by intracellular Ca2+.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.