ArticleThe Journal of clinical investigation1995
Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infection.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy.Infectious diseases of poverty · 2017Review
- Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcγ receptors.BMC immunology · 2015Article
- An in vitro model of antibody-enhanced killing of the intracellular parasite Leishmania amazonensis.PloS one · 2014Article
- Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.PloS one · 2012Article
- Delineation of regions of the Yersinia YopM protein required for interaction with the RSK1 and PRK2 host kinases and their requirement for interleukin-10 production and virulence.Infection and immunity · 2010Article
- Divergence of macrophage phagocytic and antimicrobial programs in leprosy.Cell host & microbe · 2009Article
- Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP.Blood · 2008Article
- What would Karl Landsteiner do? The ABO blood group and stem cell transplantation.Bone marrow transplantation · 2005Review
- New concepts in antibody-mediated immunity.Infection and immunity · 2004Review
- Skewed balance in basal expression and regulation of activating v inhibitory Fcgamma receptors in macrophages of collagen induced arthritis sensitive mice.Annals of the rheumatic diseases · 2003Article
- Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE.Annals of the rheumatic diseases · 2003Article
- Article
- Both Th1 and Th2 cytokines affect the ability of monoclonal antibodies to protect mice against Cryptococcus neoformans.Infection and immunity · 2001Article
- Immune complexes (IC) down-regulate the basal and interferon-gamma-induced expression of MHC class II on human monocytes.Clinical and experimental immunology · 2001Article
- Cross-linking of Fc(gamma)-receptor on monocytes inhibits hepatitis C virus-specific cytotoxic T-lymphocyte induction in vitro.Immunology · 1998Article
- Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I.The Journal of experimental medicine · 1998Article
- Production of interleukin-10 and transforming growth factor beta by peripheral blood mononuclear cells in Q fever endocarditis.Infection and immunity · 1996Article
- Upregulation of tumor necrosis factor alpha and interleukin-1 beta in Q fever endocarditis.Infection and immunity · 1996Article
- Endogenous interleukin-4, but not interleukin-10, is involved in suppression of host resistance against Listeria monocytogenes infection in interferon-depleted mice.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of soluble antigen-antibody complexes renders mice highly susceptible to infection with the intracellular pathogen Listeria monocytogenes. In this report we show that this inhibition is manifest at the level of the innate immune response and is mediated by IL-10. Like immuno-competent mice, mice with the severe combined immunodeficient mutation (SCID) injected with immune complexes died from a sublethal dose of L. monocytogenes. These mice were protected if pretreated with neutralizing antibodies to IL-10. In vitro, immune complexes stimulated IL-10 production by SCID splenocytes and splenic macrophages. Likewise, immune complexes inhibited TNF and IFN-gamma production by SCID splenocytes cultured with heat-killed-L. monocytogenes. This inhibition was reversed by neutralization of IL-10 but not IL-4 or TGF-beta. Immune complexes and rIL-10 inhibited cytokine production by SCID splenocytes if added before or simultaneously with heat-killed-L. monocytogenes. These data support a model in which immune complexes modulate host defense and the immune response by stimulating the production of IL-10 from macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.