ArticleThe Journal of clinical investigation1995
Identification of four chromosomal loci determining obesity in a multifactorial mouse model.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 181 citations in OpenAlex.
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- Genetics of murine type 2 diabetes and comorbidities.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity.Metabolites · 2022Review
- Pulmonary Effects of Adjusting Tidal Volume to Actual or Ideal Body Weight in Ventilated Obese Mice.Scientific reports · 2018Article
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- Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors.Eye and vision (London, England) · 2016Review
- Effects of 5-aminolevulinic acid on a murine model of diet-induced obesity.Journal of clinical biochemistry and nutrition · 2015Article
- In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl-/-) mice.Physiological reports · 2015Article
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- Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross.G3 (Bethesda, Md.) · 2012Article
- A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models.Biochimica et biophysica acta · 2012Article
- Four out of eight genes in a mouse chromosome 7 congenic donor region are candidate obesity genes.Physiological genomics · 2011Article
- Article
- Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats.Physiological genomics · 2010Article
- Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis.Endocrinology · 2010Article
- Maternal influence of prolyl endopeptidase on fat mass of adult progeny.International journal of obesity (2005) · 2009Article
- Evidence of maternal QTL affecting growth and obesity in adult mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Genetic influences on growth and body composition in mice: multilocus interactions.International journal of obesity (2005) · 2009Article
- QTL for body composition on chromosome 7 detected using a chromosome substitution mouse strain.Obesity (Silver Spring, Md.) · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We previously described a new mouse model for multigenic obesity, designated BSB. We now report the use of a complete linkage map approach to identify loci contributing to body fat and other traits associated with obesity in this model. Four loci exhibiting linkage with body fat, or with the weights of four different fat depots, residing on mouse chromosomes 6, 7, 12, and 15, were identified and confirmed by analysis of additional BSB mice. Each of the four loci differed with respect to their effects on the percent of body fat, specific fat depots and plasma lipoproteins. The loci exhibited allele-specific, non-additive interactions. A locus for hepatic lipase activity was co-incident with the body fat and total cholesterol loci on chromosome 7, providing a possible mechanism linking plasma lipoproteins and obesity. The chromosome 7 locus affecting body fat, total cholesterol and hepatic lipase activity was isolated in congenic strains whose donor strain regions overlap with the chromosome 7 BSB locus. These results provide candidate genes and candidate loci for the analysis of human obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.