ArticleGenetics1995
Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Continuous recording of vital signs with a wearable device in pediatric patients undergoing chemotherapy for cancer-an operational feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Observational
- Variation, Variegation and Heritable Gene Repression inFrontiers in genetics · 2021Review
- Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.Nucleic acids research · 2013Article
- Sub-telomeric core X and Y' elements in S. cerevisiae suppress extreme variations in gene silencing.PloS one · 2011Article
- Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.The EMBO journal · 2010Article
- Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.Genes & development · 2002Article
- Transcriptional silencing at Saccharomyces telomeres: implications for other organisms.Oncogene · 2002Review
- A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.Molecular and cellular biology · 1999Article
- The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction.Molecular and cellular biology · 1999Article
- Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.Molecular and cellular biology · 1998Article
- Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo.Molecular and cellular biology · 1998Article
- Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.The EMBO journal · 1998Article
- The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formation.Molecular and cellular biology · 1998Article
- The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Yeast telomeric sequences function as chromosomal anchorage points in vivo.The EMBO journal · 1997Article
- The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae.Molecular and cellular biology · 1996Article
- Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.Genetics · 1996Article
- Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Yeast telomeric DNA is assembled into a nonnucleosomal chromatin structure known as the telosome, which is thought to influence the transcriptional repression of genes placed in its vicinity, a phenomenon called telomere position effect (TPE). The product of the RAP1 gene, Rap1p, is a component of the telosome. We show that the fraction of cells exhibiting TPE can be substantially reduced by expressing large amounts of a deletion derivative of Rap1p that is unable to bind DNA, called Rap1 delta BBp, or by introducing extra telomeres on a linear plasmid, presumably because both compete in trans with telomeric chromatin for factor(s) important for TPE. This reduction in TPE, observed in three different strains, was demonstrated for two different genes, each assayed at a different telomere. In contrast, the addition of internal tracts of telomeric DNA on a circular plasmid had very little effect on TPE. The product of the SIR3 gene, Sir3p, appears to be limiting for TPE. Overexpression of Sir3p completely suppressed the reduction in TPE observed with expression of Rap1 delta BBp, but did not restore high levels of TPE to cells with extra telomeres. These results suggest that extra telomeres must titrate a factor other than Sir3p that is important for TPE. These results also provide evidence for a terminus-specific binding factor that is a factor with a higher affinity for DNA termini than for nonterminal tracts of telomeric DNA and indicate that this factor is important for TPE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.