ArticleGenetics1995
How often do duplicated genes evolve new functions?
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
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147 citing papers in PubMed, 416 citations in OpenAlex.
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- The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.bioRxiv : the preprint server for biology · 2026Article
- Directed evolution of multimeric proteins is enabled by dual-compensatory gene duplication.bioRxiv : the preprint server for biology · 2026Article
- Sex chromosome evolution in haploid plants: Microchromosomes, disappearing chromosomes, and giant chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2025Review
- Systematic analysis of paralogous regions in 41,755 exomes uncovers clinically relevant variation.Nature communications · 2023Article
- Comparative gene retention analysis in barley, wild emmer, and bread wheat pangenome lines reveals factors affecting gene retention following gene duplication.BMC biology · 2023Article
- The evolutionary patterns, expression profiles, and genetic diversity of expanded genes in barley.Frontiers in plant science · 2023Article
- The activity of the stress modulated Arabidopsis ubiquitin ligases PUB46 and PUB48 is partially redundant.Plant signaling & behavior · 2022Article
- Circadian regulation of the transcriptome in a complex polyploid crop.PLoS biology · 2022Article
- A Population-Genetic Lens into the Process of Gene Loss Following Whole-Genome Duplication.Molecular biology and evolution · 2022Article
- Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans.Nature ecology & evolution · 2022Article
- Genome-wide characterization, evolution, structure, and expression analysis of the F-box genes in Caenorhabditis.BMC genomics · 2021Article
- Niche adaptation promoted the evolutionary diversification of tiny ocean predators.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genome-wide identification and evolutionary analysis of RLKs involved in the response to aluminium stress in peanut.BMC plant biology · 2021Article
- A Screen for Gene Paralogies Delineating Evolutionary Branching Order of Early Metazoa.G3 (Bethesda, Md.) · 2020Article
- An evolving view of copy number variants.Current genetics · 2019Review
- Recent emergence and extinction of the protection of telomeres 1c gene in Arabidopsis thaliana.Plant cell reports · 2019Article
- Gene duplications in the E. coli genome: common themes among pathotypes.BMC genomics · 2019Article
- Article
87 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recently duplicated gene can either fix a null allele (becoming a pseudogene) or fix an (advantageous) allele giving a slightly different function, starting it on the road to evolving a new function. Here we examine the relative probabilities of these two events under a simple model. Null alleles are assumed to be neutral; linkage effects are ignored, as are unequal crossing over and gene conversion. These assumptions likely make our results underestimates for the probability that an advantageous allele is fixed first. When new advantageous mutations are additive with selection coefficient s and the ratio of advantageous to null mutations is rho, the probability an advantageous allele is fixed first is ([1 - e-s]/[rho S] + 1)-1, where S = 4Nes with Ne the effective population size. The probability that a duplicate locus becomes a pseudogene, as opposed to evolving a new gene function, is high unless rhoS >> 1. However, even if advantageous mutations are very rare relative to null mutations, for sufficiently large populations rhoS >> 1 and new gene function, rather than pseudogene formation, is the expected fate of most duplicated genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.