ArticleGenetics1995
Identification of target genes regulated by homeotic proteins in Drosophila melanogaster through genetic selection of Ultrabithorax protein-binding sites in yeast.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 84 citations in OpenAlex.
- Role of the Hox Genes,International journal of molecular sciences · 2023Article
- Drosophila Hox genes induce melanized pseudo-tumors when misexpressed in hemocytes.Scientific reports · 2021Article
- Staggered Hox expression is more widespread among molluscs than previously appreciated.Proceedings. Biological sciences · 2018Article
- Making sense of transcription networks.Cell · 2015Review
- BAF-1 mobility is regulated by environmental stresses.Molecular biology of the cell · 2014Article
- Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor.Journal of molecular biology · 2009Article
- Multiple intrinsically disordered sequences alter DNA binding by the homeodomain of the Drosophila hox protein ultrabithorax.The Journal of biological chemistry · 2008Article
- Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins.Nucleic acids research · 2008Article
- Hox genes and their candidate downstream targets in the developing central nervous system.Cellular and molecular neurobiology · 2005Review
- Phylogeny of the insect homeobox gene (hox) cluster.Genomics, proteomics & bioinformatics · 2005Article
- Expression profiling of homeobox genes in silk gland development in the mulberry silkworm Bombyx mori.Development genes and evolution · 2003Article
- Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging.Genome biology · 2001Article
- Article
- Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity.Genes & development · 1998Article
- SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.Molecular biology of the cell · 1997Article
- Mating types and sexual development in filamentous ascomycetes.Microbiology and molecular biology reviews : MMBR · 1997Review
- Selective constraints on the activation domain of transcription factor Pit-1.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster.Genetics · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A method based on the transcriptional activation of a selectable reporter in yeast cells was used to identify genes regulated by the Ultrabithorax homeoproteins in Drosophila melanogaster. Fifty-three DNA fragments that can mediate activation by UBX isoform Ia in this test were recovered after screening 15% of the Drosophila genome. Half of these fragments represent single-copy sequences in the genome. Six single-copy fragments were investigated in detail, and each was found to reside near a transcription unit whose expression in the embryo is segmentally modulated as expected for targets of homoeotic genes. Four of these putative target genes are expressed in patterns that suggest roles in the development of regional specializations within mesoderm derivatives; in three cases these expression patterns depend on Ultrabithorax function. Extrapolation from this pilot study indicates that 85-170 candidate target genes can be identified by screening the entire Drosophila genome with UBX isoform Ia. With appropriate modifications, this approach should be applicable to other transcriptional regulators in diverse organisms.
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