ArticleJournal of neuro-oncology1994
Cytokine gene expression on glioma cell lines and specimens.
Article in Journal of neuro-oncology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
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- Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas.British journal of cancer · 2020Article
- RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme.Oncogenesis · 2019Article
- Pediatric glioblastoma cells inhibit neurogenesis and promote astrogenesis, phenotypic transformation and migration of human neural progenitor cells within cocultures.Experimental cell research · 2018Article
- Pre-exposure of human adipose mesenchymal stem cells to soluble factors enhances their homing to brain cancer.Stem cells translational medicine · 2015Article
- Interleukin-1β promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production.Cell death & disease · 2014Article
- Immunomodulatory nature and site specific affinity of mesenchymal stem cells: a hope in cell therapy.Advanced pharmaceutical bulletin · 2014Review
- iNOS: a potential therapeutic target for malignant glioma.Current molecular medicine · 2013Review
- Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation.Stem cells and development · 2013Article
- Interleukins in glioblastoma pathophysiology: implications for therapy.British journal of pharmacology · 2013Review
- In silico experimentation of glioma microenvironment development and anti-tumor therapy.PLoS computational biology · 2012Article
- STAT3 regulation of glioblastoma pathogenesis.Current molecular medicine · 2009Review
- Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model.Neuro-oncology · 2005Article
- Cell kinetic analysis in recurrent neuro-epithelial tumours.Acta neurochirurgica · 1996Article
- Growth inhibition of human glioma cells modulated by retrovirus gene transfection with antisense IL-8.Journal of neuro-oncology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the cytokine genes in human glioma cell lines and specimens was studied. Primers for 7 different human cytokine, IL-1 beta, IL-6, IL-8, GM-CSF, TGF-beta 1, TNF-alpha and IFN-gamma were used to analyze messenger RNA transcripts by polymerase chain reaction (PCR). Messenger RNA encoding for IL-1 beta, IL-6, IL-8, GM-CSF and TGF-beta 1 was found to be expressed in some of glioma cell lines. And those showed a proliferative response to IL-1 beta. IL-8 mRNA was found in 2 of 5 low grade gliomas, in 8 of 9 high grade gliomas. TGF-beta 1 mRNA was found in all gliomas, in 1 of 2 normal brains. IL-1 beta mRNA was only found in normal brains. TNF-alpha and IFN-gamma were not found in glioma cell lines and specimens. IL-8 mRNA was apt to be found more frequently among high grade glioma specimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.