ArticleEnvironmental health perspectives1994
Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes.
Article in Environmental health perspectives, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 citations in OpenAlex.
- CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Trial
- Interaction between grapefruit juice and diazepam in humans.European journal of drug metabolism and pharmacokineticsTrial
- Constipation-associated factors in outpatients with schizophrenia: A multicenter questionnaire survey.Neuropsychopharmacology reports · 2024Article
- Nanocarriers for natural polyphenol senotherapeutics.Aging cell · 2024Review
- May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects.Frontiers in nutrition · 2022Review
- Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma.Life sciences · 2013Article
- Age-related changes in the mRNA levels of CYP1A1, CYP2B1/2 and CYP3A1 isoforms in rat small intestine.Genes & nutrition · 2012Article
- Toxicological aspects of the use of phenolic compounds in disease prevention.Interdisciplinary toxicology · 2011Article
- Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.Cancer letters · 2010Article
- Evaluation of in vitro assays for assessing the toxicity of cigarette smoke and smokeless tobacco.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Review
- Phenotypic CYP2A6 variation and the risk of pancreatic cancer.JOP : Journal of the pancreas · 2009Article
- Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry.Journal of proteome research · 2009Article
- Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions.Clinical pharmacokinetics · 1997Review
- Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.Clinical pharmacokinetics · 1995Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Human cytochrome P450 (P450) enzymes are involved in the oxidation of natural products found in foods, beverages, and tobacco products and their catalytic activities can also be modulated by components of the materials. The microsomal activation of aflatoxin B1 to the exo-8,9-epoxide is stimulated by flavone and 7,8-benzoflavone, and attenuated by the flavonoid naringenin, a major component of grapefruit. P4502E1 has been demonstrated to play a potentially major role in the activation of a number of very low-molecular weight cancer suspects, including ethyl carbamate (urethan), which is present in alcoholic beverages and particularly stone brandies. The enzyme (P4502E1) is also known to be inducible by ethanol. Tobacco contains a large number of potential carcinogens. In human liver microsomes a significant role for P4501A2 can be demonstrated in the activation of cigarette smoke condensate. Some of the genotoxicity may be due to arylamines. P4501A2 is also inhibited by components of crude cigarette smoke condensate. The tobacco-specific nitrosamines are activated by a number of P450 enzymes. Of those known to be present in human liver, P4501A2, 2A6, and 2E1 can activate these nitrosamines to genotoxic products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.