ArticleVirchows Archiv : an international journal of pathology1995
The expression of placental-type glutathione S-transferase (GST-pi) in human cutaneous squamous cell carcinoma and normal human skin.
Article in Virchows Archiv : an international journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 18 citations in OpenAlex.
- Expression of placental glutathione S-transferase in rat tongue mucosa exposed to cigarette smoke.Journal of molecular histology · 2008Article
- Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme.The Biochemical journal · 2003Article
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3 authors at 2 institutions in 2 countries.
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Abstract
The expression of human placental-type glutathione S-transferase (GST-pi) was investigated in human cutaneous squamous cell carcinoma (SCC) and normal skin using Northern blot and immunohistochemical analysis. In Northern blot examination, the expression of GST-pi transcript was recognized in all instances, and SCC showed a significantly higher expression of GST-pi than normal skin. In immunohistochemical examination, GST-pi was stained well in the cytoplasm of all cells of the stratum granulosum, many cells of the stratum spinosum and a few cells of the stratum basale in normal skin. Some cells of the stratum spinosum and almost all cells of the stratum basale showed only a weakly positive or almost negative reaction for GST-pi. No nuclear staining of GST-pi was obvious in normal epidermal cells. In SCC, many cells showed strong positivity for GST-pi in the cytoplasm, and some were obviously accompanied by nuclear staining of GST-pi. These findings suggest that GST-pi exists mainly in many cells in the upper layers of the normal epidermis and that GST-pi is involved in the process of carcinogenesis.
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