ArticleBiophysical journal1994
The fundamental motor of the human neutrophil is not random: evidence for local non-Markov movement in neutrophils.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Review
- Cell migration: Beyond Brownian motion.Biophysical journal · 2024Article
- Random walk and cell morphology dynamics inFrontiers in cell and developmental biology · 2023Article
- Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.Cell systems · 2020Article
- Stochastic and Heterogeneous Cancer Cell Migration: Experiment and Theory.Scientific reports · 2019Article
- Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.Developmental cell · 2019Article
- Self-organization of protrusions and polarity during eukaryotic chemotaxis.Current opinion in cell biology · 2014Review
- Microfluidic platform for the quantitative analysis of leukocyte migration signatures.Nature communications · 2014Article
- Velocity alignment leads to high persistence in confined cells.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- 'Dicty dynamics': Dictyostelium motility as persistent random motion.Physical biology · 2011Article
- Zigzag turning preference of freely crawling cells.PloS one · 2011Article
- Directional decisions during neutrophil chemotaxis inside bifurcating channels.Integrative biology : quantitative biosciences from nano to macro · 2010Article
- Article
- Bipedal locomotion in crawling cells.Biophysical journal · 2010Article
- Persistent cell motion in the absence of external signals: a search strategy for eukaryotic cells.PloS one · 2008Article
- Anomalous dynamics of cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Characteristics of motive force derived from trajectory analysis of Amoeba proteus.Protoplasma · 2007Article
- Cell motility as persistent random motion: theories from experiments.Biophysical journal · 2005Article
- Cellular memory: neutrophil orientation reverses during temporally decreasing chemoattractant concentrations.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The search for a fundamental mechano-chemical process that results in net cell motion has led investigators to fit neutrophil tracking data to well described physical models in hopes of understanding the functional form of the driving force. The Ornstein-Uhlenbeck (OU) equation for mean square displacement describes a locally persistent and globally random process and is often used as a starting point for analysis of neutrophil displacements. Based upon the apparently close fit of neutrophil tracking data to this equation and the nature of its derivation, biologists have inferred that the motor of the neutrophil is best represented as a random process. However, 24 of 37 neutrophil paths that we investigated preferentially display programmatic rather than Markov short term correlations between displacements or turn angles. These correlations reflect a bimodal rather than a uniform distribution of subpath correlations in the two variables, and are strongly sampling rate-dependent. Significant periodic components of neutrophil shape change are also detected at the same time scale using either Fourier or elliptical Fourier transform-based descriptors of the neutrophil perimeter. Oscillations in neutrophil velocity have the same period. Taken together, these data suggest a nonstochastic, and perhaps periodic, component to the process driving neutrophil movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.