ArticleBiophysical journal1994
Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00846092 (Phase 1 Study To Determine the Effects of Short Term Near-infrared Light), which is not on this map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.
Who cites it
34 citing papers in PubMed, 225 citations in OpenAlex.
- Photobiomodulation on isolated mitochondria at 810 nm: first results on the efficiency of the energy conversion process.Scientific reports · 2024Article
- Integration of cellular-resolution optical coherence tomography and Raman spectroscopy for discrimination of skin cancer cells with machine learning.Journal of biomedical optics · 2023Article
- Spectral analysis of multiple scattering factors of turbid media for glucose measurement using near-infrared spectroscopy.Journal of biomedical optics · 2023Article
- Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models.International journal of molecular sciences · 2023Article
- Innovative Strategies for Hair Regrowth and Skin Visualization.Pharmaceutics · 2023Review
- Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- Cytoklepty in the plankton: A host strategy to optimize the bioenergetic machinery of endosymbiotic algae.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Electromagnetic Dosimetry for Isolated Mitochondria Exposed to Near-Infrared Continuous-Wave Illumination in Photobiomodulation Experiments.Bioelectromagnetics · 2021Article
- Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation.Photochemistry and photobiology · 2018Review
- Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss.International journal of obesity (2005) · 2016Article
- Differences in forward angular light scattering distributions between M1 and M2 macrophages.Journal of biomedical optics · 2015Article
- Physiological strategies during animal diapause: lessons from brine shrimp and annual killifish.The Journal of experimental biology · 2015Review
- Gold Nanorod-assisted Optical Stimulation of Neuronal Cells.Journal of visualized experiments : JoVE · 2015Article
- Optical properties of tissues quantified using morphological granulometry from phase-contrast images of thin tissue samples.Journal of X-ray science and technology · 2015Article
- Pre-conditioning with low-level laser (light) therapy: light before the storm.Dose-response : a publication of International Hormesis Society · 2014Article
- Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: in vivo and in vitro.Investigative ophthalmology & visual science · 2013Article
- Correlating light scattering with internal cellular structures.Biomedical optics express · 2012Article
- Article
- Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice.Parkinson's disease · 2012Article
- Effects of low-power laser irradiation (LPLI) at different wavelengths and doses on oxidative stress and fibrogenesis parameters in an animal model of wound healing.Lasers in medical science · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this work was to analyze the contribution of the mitochondria to the optical properties, i.e., light absorption and scattering, of the blood-free rat liver. Firstly, a theoretical model of the reduced scattering coefficient of the liver was performed by using the Mie theory, the Rayleigh-Debye-Gans approximation, and the electron microscopy descriptions of the liver ultrastructure. Compared with the hepatocyte volume, the nucleus and the peroxisomes, the mitochondria compartment, accounting for 22% of the liver cell volume, seemed to be the predominant factor for the light scattering of the liver. Second, by using time-resolved spectroscopy and a sample substitution method, we have measured the absorption and reduced scattering coefficients of blood-free perfused rat livers, isolated hepatocyte suspensions, and isolated mitochondria suspensions. A subsequent extrapolation of the isolated mitochondria data to the in vivo mitochondrial content and a comparison with the whole liver measurements lead to the following conclusions: 1) the mitochondria account for about 50% of the liver absorption coefficient at 780 nm (mu a = 0.25 cm-1 extrapolated from isolated mitochondria vs. 0.53 +/- 0.05 cm-1 measured for the liver); and 2) the mitochondrial compartment is the primary factor for the light scattering in the rat liver (mu s' = 15.5 cm-1 extrapolated from the isolated mitochondria versus 15.9 +/- 2.4 cm-1 measured for the liver), demonstrating the relevancy of our preliminary theoretical study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.