ArticleProceedings of the National Academy of Sciences of the United States of America1993
Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function.Molecular and cellular neurosciences · 2017Review
- Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury.Journal of molecular histology · 2013Article
- Tropomyosin isoforms and reagents.Bioarchitecture · 2011Article
- New insights into the regulation of the actin cytoskeleton by tropomyosin.International review of cell and molecular biology · 2010Review
- Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD.Journal of proteome research · 2009Article
- Do distantly related parasites rely on the same proximate factors to alter the behaviour of their hosts?Proceedings. Biological sciences · 2006Article
- Specific features of neuronal size and shape are regulated by tropomyosin isoforms.Molecular biology of the cell · 2005Article
- Gamma tropomyosin gene products are required for embryonic development.Molecular and cellular biology · 2004Article
- Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts.Molecular and cellular biology · 2003Article
- Specification of actin filament function and molecular composition by tropomyosin isoforms.Molecular biology of the cell · 2003Article
- Mathematical modeling of noise and discovery of genetic expression classes in gliomas.Oncogene · 2002Article
- Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts.Molecular biology of the cell · 1997Article
- Restricted expression of the actin-regulatory protein, tropomyosin, defines distinct boundaries, evaginating neuroepithelium, and choroid plexus forerunners during early CNS development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- A sequence compilation and comparison of exons that are alternatively spliced in neurons.Nucleic acids research · 1994Article
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4 authors.
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Abstract
In this study we report on the developmental and regional expression of two brain-specific isoforms of tropomyosin, TMBr-1 and TMBr-3, that are generated from the rat alpha-tropomyosin gene via the use of alternative promoters and alternative RNA splicing. Western blot analysis using an exon-specific peptide polyclonal antibody revealed that the two isoforms are differentially expressed in development with TMBr-3 appearing in the embryonic brain at 16 days of gestation, followed by the expression of TMBr-1 at 20 days after birth. TMBr-3 was detected in all brain regions examined, whereas TMBr-1 was detected predominantly in brain areas that derived from the prosencephalon. Immunocytochemical studies on mixed primary cultures made from rat embryonic midbrain indicate that expression of the brain-specific epitope is restricted to neurons. The developmental pattern and neuronal localization of these forms of tropomyosin suggest that these isoforms have a specialized role in the development and plasticity of the nervous system.
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