ArticleJournal of virology1993
Characterization of the Ld-restricted cytotoxic T-lymphocyte epitope in the mouse hepatitis virus nucleocapsid protein.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis.Immunology · 2015Article
- Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection.Journal of virology · 2010Article
- NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis.Journal of virology · 2008Article
- Structural proteomics of the SARS coronavirus: a model response to emerging infectious diseases.Journal of structural and functional genomics · 2007Review
- Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus.Microbiology and molecular biology reviews : MMBR · 2005Review
- Structural insights into SARS coronavirus proteins.Current opinion in structural biology · 2005Review
- Virus-specific and bystander CD8 T cells recruited during virus-induced encephalomyelitis.Journal of virology · 2005Article
- Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus.Journal of virology · 2004Article
- Antibody-mediated protection against cytotoxic T-cell escape in coronavirus-induced demyelination.Journal of virology · 2003Article
- Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection.Journal of virology · 2003Article
- B-cell-mediated lysis of cells infected with the neurotropic JHM strain of mouse hepatitis virus.Virology · 2001Article
- Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue.Journal of virology · 1997Article
- Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.Journal of virology · 1997Article
- Cooperation between transmissible gastroenteritis coronavirus (TGEV) structural proteins in the in vitro induction of virus-specific antibodies.Virus research · 1996Article
- Specificity of the H-2 L(d)-restricted cytotoxic T-lymphocyte response to the mouse hepatitis virus nucleocapsid protein.Journal of virology · 1996Article
- Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice.European journal of immunology · 1995Article
- Predominance of MHC class II-restricted CD4+ cytotoxic T cells against mouse hepatitis virus A59.Immunology · 1995Article
- Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system.Journal of virology · 1995Article
- MHC ligands and peptide motifs: first listing.Immunogenetics · 1995Review
- Immunopathological aspects of coronavirus infections.Springer seminars in immunopathology · 1995Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mouse hepatitis virus (MHV) JHM strain (JHMV) produces primary demyelination in the central nervous system associated with acute encephalomyelitis. Humoral and cellular immune responses both participate in controlling the development of chronic MHV-induced demyelination. A subset of the CD8+ cytotoxic T lymphocytes (CTL) induced by immunization of BALB/c (H-2d) mice with JHMV is specific for the viral nucleocapsid protein. This CTL population recognizes an epitope located within the carboxy-terminal 149 amino acids in association with the Ld class I molecule (S. A. Stohlman, S. Kyuwa, M. Cohen, C. Bergmann, J. P. Polo, J. Yeh, R. Anthony, and J. G. Keck, Virology 189:217-224, 1992). Using a panel of vaccinia virus recombinants expressing truncated forms of the nucleocapsid protein and a series of overlapping synthetic peptides, we mapped the response to 15 amino acids. This sequence, encompassing the MHV epitope, contains the Ld-specific binding motif. The predicted 9-mer peptide (residues 318 to 326: APTAGAFFF) was sufficient and highly active in sensitizing target cells for CTL recognition when either added exogenously or synthesized intracellularly. Cross-reactivity of JHMV nucleocapsid protein-specific CTL with six other MHV strains indicated that natural sequence variations within the 9-mer epitope are tolerated in positions 4 and 5, whereas all other amino acids are conserved. These data define a novel 9-mer Ld-restricted CTL epitope which represents the first MHV CTL epitope. Characterization of this epitope provides a molecular basis to study the role of nucleocapsid protein-specific CTL in the clearance of JHMV from the central nervous system.
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