ArticleHistochemistry1993
Distribution and morphological features of nitrergic neurons in the porcine large intestine.
Article in Histochemistry, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon.Cell and tissue research · 2021Article
- Architecture and Chemical Coding of the Inner and Outer Submucous Plexus in the Colon of Piglets.PloS one · 2015Article
- Secretion of immunomodulating neuropeptides (VIP, SP) and nitric oxide synthase in porcine small intestine during postnatal development.European journal of histochemistry : EJH · 2012Article
- NADPH- diaphorase positive cardiac neurons in the atria of mice. A morphoquantitative study.BMC neuroscience · 2006Article
- Relaxation by vasoactive intestinal polypeptide in the gastric fundus of nitric oxide synthase-deficient mice.The Journal of physiology · 2002Article
- Article
- Distribution of NADPH diaphorase-positive neurons in the enteric nervous system of the rabbit intestine.Neurochemical research · 1998Article
- Intrinsic innervation of the chicken lower digestive tract.Neurochemical research · 1997Article
- Study of NO and VIP as non-adrenergic non-cholinergic neurotransmitters in the pig gastric fundus.British journal of pharmacology · 1995Article
- Histochemistry of nitric oxide synthase in the nervous system.The Histochemical journal · 1995Review
- The distribution and co-localization of immunoreactivity to nitric oxide synthase, vasoactive intestinal polypeptide and substance P within nerve fibres supplying bovine and porcine female genital organs.Cell and tissue research · 1995Article
- Nitrergic inhibitory innervation of porcine rectal circular smooth muscle.The British journal of surgery · 1995Article
- Vasoactive intestinal polypeptide and nitric oxide synthase distribution in the enteric plexuses of the human colon: an histochemical study and quantitative analysis.Histochemistry and cell biology · 1995Article
- Colocalization of NADPH-diaphorase staining and VIP immunoreactivity in neurons in opossum internal anal sphincter.Digestive diseases and sciences · 1995Article
- Projections of neurochemically specified neurons in the porcine colon.Histochemistry and cell biology · 1995Article
- Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description.Cell and tissue research · 1994Article
- Appearance and some neurochemical features of nitrergic neurons in the developing quail digestive tract.Histochemistry · 1994Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of nitric oxide synthase (NOS), an enzyme involved in the synthesis of the presumed non-adrenergic noncholinergic inhibitory neurotransmitter nitric oxide (NO), was demonstrated in the enteric nervous system of the porcine caecum, colon and rectum. Techniques used were NOS-immunocytochemistry and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-histochemistry. Throughout the entire large intestine, NOS-immunoreactive (IR) and NADPHd-positive neurons were abundant in the myenteric and outer submucous plexus. In the inner submucous plexus, only a small number of positive neurons were found in the caecum and colon, while a moderate number was observed in the rectum. The nitrergic neurons in the porcine enteric nerve plexuses were of a range of sizes and shapes, with a small proportion showing immunostaining for vasoactive intestinal polypeptide. Varicose and non-varicose NOS-IR and NADPHd-positive nerve fibres were present in the ganglia and connecting strands of all three plexuses. Nerve fibres were also numerous in the circular muscle layer, scarce in the longitudinal muscle coat and negligible in the mucosal region. The abundance of NOS/NADPHd in the intrinsic innervation of the caecum, colon and rectum of the pig implicates NO as an important neuronal messenger in these regions of the gastrointestinal tract.
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