ArticlePflugers Archiv : European journal of physiology1993
Multiple effects of caffeine on calcium current in rat ventricular myocytes.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Calcium Signaling and Contractility in Cardiac Myocyte of Wolframin Deficient Rats.Frontiers in physiology · 2019Article
- Calcium release-dependent inactivation precedes formation of the tubular system in developing rat cardiac myocytes.European biophysics journal : EBJ · 2017Article
- Optical recording of calcium currents during impulse conduction in cardiac tissue.Neurophotonics · 2015Article
- Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle.Molecular pharmacology · 2014Article
- Calcium spike variability in cardiac myocytes results from activation of small cohorts of ryanodine receptor 2 channels.The Journal of physiology · 2012Article
- Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes.The Journal of physiology · 2008Article
- Kinetics of calcium spikes in rat cardiac myocytes.The Journal of physiology · 2007Article
- A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.Biophysical journal · 2004Article
- Modulators of internal Ca2+ stores and the spontaneous electrical and contractile activity of the guinea-pig renal pelvis.British journal of pharmacology · 2002Article
- One calcium ion may suffice to open the tetrameric cardiac ryanodine receptor in rat ventricular myocytes.The Journal of physiology · 1999Article
- Caffeine-induced oscillations of cytosolic Ca2+ in GH3 pituitary cells are not due to Ca2+ release from intracellular stores but to enhanced Ca2+ influx through voltage-gated Ca2+ channels.Pflugers Archiv : European journal of physiology · 1996Article
- Ryanodine receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurones.The Journal of physiology · 1995Article
- Veratridine-induced oscillations of cytosolic calcium and membrane potential in bovine chromaffin cells.The Journal of physiology · 1995Article
- Mechanical restitution and recirculation fraction in cardiac myocytes and left ventricular muscle of adult rats.Basic research in cardiologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Caffeine exerts a number of different effects on L-type calcium current in rat ventricular myocytes. These include: (1) a slowing of inactivation that is comparable to, but not additive to, that produced by prior treatment of the cells with ryanodine (a selective sarcoplasmic reticulum Ca2+ releaser) or high concentrations of intracellular 1,2-bis[2-aminophenoxy]ethane-N,N,N',-N'-tetraacetic acid (BAPTA) (a fast Ca2+ chelator), (2) a stimulation of peak ICa that is comparable to, but not additive to that produced by prior treatment with isobutylmethylxanthine (a selective phosphodiesterase inhibitor), and (3) a dose-dependent decrease of peak ICa that is not prevented by pretreatment with any of these agents. None of the caffeine actions could be mimicked or prevented by administration of 8-phenyltheophylline, a specific adenosine receptor antagonist. We conclude that only the slowing of ICa inactivation is due to caffeine's ability to deplete the sarcoplasmic reticulum of calcium. The stimulatory effect of caffeine on peak ICa is probably due to phosphodiesterase inhibition, while caffeine's inhibitory effect on ICa is independent of these processes and could be a direct effect on the channel. The multiplicity of caffeine actions independent of its effects on the sarcoplasmic reticulum lead to the conclusion that ryanodine, though slower acting and essentially irreversible, is a more selective agent than caffeine for probing sarcoplasmic reticulum function and its effects on other processes.
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