ArticleMolecular and cellular biology1993
Alu sequence involvement in transcriptional insulation of the keratin 18 gene in transgenic mice.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 60 citations in OpenAlex.
- Review
- Article
- Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation.Nucleic acids research · 2007Article
- A CBF5 mutation that disrupts nucleolar localization of early tRNA biosynthesis in yeast also suppresses tRNA gene-mediated transcriptional silencing.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Article
- Regulation of keratin and integrin gene expression in cancer and drug resistance.Cytotechnology · 1998Article
- Structure and upstream region characterization of the human gene encoding rod photoreceptor cGMP phosphodiesterase alpha-subunit.Journal of molecular neuroscience : MN · 1998Article
- Intergenic transcription and transinduction of the human beta-globin locus.Genes & development · 1997Article
- Methylation of an ETS site in the intron enhancer of the keratin 18 gene participates in tissue-specific repression.Molecular and cellular biology · 1997Article
- Recent advances in transgenic technology.Molecular biotechnology · 1997Review
- Sheltering of gamma-globin expression from position effects requires both an upstream locus control region and a regulatory element 3' to the A gamma-globin gene.Molecular and cellular biology · 1997Article
- Oncogenic regulation and function of keratins 8 and 18.Cancer metastasis reviews · 1996Review
- DNA sequence insertion and evolutionary variation in gene regulation.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Contrasting effects of the SATB1 core nuclear matrix attachment region and flanking sequences of the keratin 18 gene in transgenic mice.Molecular biology of the cell · 1996Article
- A BC200-derived element and Z-DNA as structural markers in annexin I genes: relevance to Alu evolution and annexin tetrad formation.Journal of molecular evolution · 1995Article
- The consensus sequence of a major Alu subfamily contains a functional retinoic acid response element.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- AP-1, ETS, and transcriptional silencers regulate retinoic acid-dependent induction of keratin 18 in embryonic cells.Molecular and cellular biology · 1994Article
- Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice.Nucleic acids research · 1994Article
- Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The human keratin 18 (K18) gene is expressed in a variety of adult simple epithelial tissues, including liver, intestine, lung, and kidney, but is not normally found in skin, muscle, heart, spleen, or most of the brain. Transgenic animals derived from the cloned K18 gene express the transgene in appropriate tissues at levels directly proportional to the copy number and independently of the sites of integration. We have investigated in transgenic mice the dependence of K18 gene expression on the distal 5' and 3' flanking sequences and upon the RNA polymerase III promoter of an Alu repetitive DNA transcription unit immediately upstream of the K18 promoter. Integration site-independent expression of tandemly duplicated K18 transgenes requires the presence of either an 825-bp fragment of the 5' flanking sequence or the 3.5-kb 3' flanking sequence. Mutation of the RNA polymerase III promoter of the Alu element within the 825-bp fragment abolishes copy number-dependent expression in kidney but does not abolish integration site-independent expression when assayed in the absence of the 3' flanking sequence of the K18 gene. The characteristics of integration site-independent expression and copy number-dependent expression are separable. In addition, the formation of the chromatin state of the K18 gene, which likely restricts the tissue-specific expression of this gene, is not dependent upon the distal flanking sequences of the 10-kb K18 gene but rather may depend on internal regulatory regions of the gene.
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