ArticleThe Journal of cell biology1993
Identification of the carboxy terminus as important for the isoform-specific subcellular targeting of glucose transporter proteins.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells.Journal of cell science · 2013Article
- ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in skeletal muscle.PloS one · 2013Article
- Elucidation of the glucose transport pathway in glucose transporter 4 via steered molecular dynamics simulations.PloS one · 2011Article
- Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.Journal of cell science · 2010Article
- Amino acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions.Molecular and cellular biochemistry · 2010Article
- Nutritional channels in breast cancer.Journal of cellular and molecular medicine · 2009Article
- The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles.The Biochemical journal · 2009Article
- An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.The Biochemical journal · 2009Article
- Molecular mechanisms controlling GLUT4 intracellular retention.Molecular biology of the cell · 2008Article
- p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation.Molecular biology of the cell · 2005Article
- Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations.Molecular and cellular biology · 2001Article
- The cytosolic C-terminus of the glucose transporter GLUT4 contains an acidic cluster endosomal targeting motif distal to the dileucine signal.The Biochemical journal · 2000Article
- Subcellular trafficking kinetics of GLU4 mutated at the N- and C-terminal.The Biochemical journal · 1996Article
- Analysis of the structural features of the C-terminus of GLUT1 that are required for transport catalytic activity.The Biochemical journal · 1995Article
- Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment.The Journal of cell biology · 1995Article
- Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes.The Journal of cell biology · 1995Article
- Possible domains responsible for intracellular targeting and insulin-dependent translocation of glucose transporter type 4.The Biochemical journal · 1995Article
- Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.The Journal of cell biology · 1995Article
- Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail.The Journal of cell biology · 1995Article
- The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain.The Journal of cell biology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Differential trafficking of glucose transporters contributes significantly to the establishment of a cell's capacity for hormone-regulatable hexose uptake. In the true insulin-sensitive peripheral target tissues, muscle and adipose, the transporter isoform GLUT1 residues on the cell surface and interior of the cell whereas the highly homologous isoform GLUT4 displays virtually exclusive intracellular sequestration, allowing the latter to redistribute to the cell surface in response to hormone. These patterns are equally pronounced in cells into which the transporters have been introduced by DNA-mediated gene transfer, suggesting that signals for isoform-specific sorting are recognized in diverse cell types. To determine the primary sequences responsible for the characteristic distributions, chimeric transporters were constructed in which reciprocal domains were exchanged between GLUT1 and GLUT4. In addition, a non-disruptive, species-specific epitope "tag" was introduced into a neutral region of the transporter to allow analysis of reciprocal chimeras using a single antibody. These recombinant transporters were stably expressed in HIH 3T3 and PC12 cells by retrovirus-mediated gene transfer, and were localized by indirect immunofluorescence and laser scanning confocal microscopy, as well as by staining of plasma membrane sheets prepared from these cells. The results indicate that the carboxy-terminal 30 amino acids are primarily responsible for the differential targeting of the glucose transporter isoforms GLUT1 and GLUT4, though there is a lesser additional contribution by the amino-terminal 183 amino acids.
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