ArticleProceedings of the National Academy of Sciences of the United States of America1993
Chimeric tumor necrosis factor-TrkA receptors reveal that ligand-dependent activation of the TrkA tyrosine kinase is sufficient for differentiation and survival of PC12 cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Glioactive ATP controls BDNF recycling in cortical astrocytes.Communicative & integrative biology · 2017Article
- Article
- Pathophysiological mechanisms for actions of the neurotrophins.Brain pathology (Zurich, Switzerland) · 2006Review
- Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells.Journal of neuroinflammation · 2005Article
- Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor.Journal of molecular neuroscience : MN · 2000Article
- Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain?Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells.Journal of molecular neuroscience : MN · 1997Article
- p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase.The EMBO journal · 1996Article
- Mutational studies of conserved residues in the dimer interface of nerve growth factor.Protein science : a publication of the Protein Society · 1996Article
- Article
- A rapid bioassay for platelet-derived growth factor beta-receptor tyrosine kinase function.Bio/technology (Nature Publishing Company) · 1994Article
- TrkA cross-linking mimics neuronal responses to nerve growth factor.Molecular biology of the cell · 1994Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To elucidate the function of the two nerve growth factor (NGF) receptors, p75NGFR and p140trk, chimeric molecules were constructed of tumor necrosis factor (TNF) and NGF receptors. Rat PC12 pheochromocytoma cells transiently transfected with TNF-p140trk chimeras, which contain the extracellular domain of TNF receptor and the transmembrane and cytoplasmic domains of p140trk, showed TNF-dependent neuronal differentiation and cell survival. The activity of TNF-p140trk chimeras was completely blocked by the tyrosine kinase inhibitor K252a, and TNF was unable to induce neurite elongation in PC12 cells transfected with a tyrosine kinase-defective chimeric receptor. The TNF-p75NGFR chimeras, which contain the cytoplasmic domain of p75NGFR, were nonfunctional. Our results suggest that p140trk may function as ligand-activated homodimers and that ligand-mediated activation of the cytoplasmic domain of p140trk alone is sufficient for inducing a neuronal phenotype.
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