ArticleThe Biochemical journal1993
Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck.
Article in The Biochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Review
- Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.Oncotarget · 2015Review
- Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells.The Journal of biological chemistry · 2015Article
- Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Interleukin-2 receptor signaling in regulatory T cell development and homeostasis.Immunology letters · 2007Review
- Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Role of vav1 in the lipopolysaccharide-mediated upregulation of inducible nitric oxide synthase production and nuclear factor for interleukin-6 expression activity in murine macrophages.Clinical and diagnostic laboratory immunology · 2004Article
- Regulatory and signaling properties of the Vav family.Molecular and cellular biology · 2000Review
- Article
- Recent advances in the understanding of interleukin-2 signal transduction.Journal of clinical immunology · 1998Review
- Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- p95vav associates with the nuclear protein Ku-70.Molecular and cellular biology · 1996Article
- A functional T-cell receptor signaling pathway is required for p95vav activity.Molecular and cellular biology · 1995Article
- Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins.Molecular and cellular biology · 1995Article
- Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation.The Biochemical journal · 1995Article
- Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.The EMBO journal · 1995Article
- The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.The EMBO journal · 1995Article
- Hematopoietic development of vav-/- mouse embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The haematopoietic protein, p95vav, has been shown to be a tyrosine kinase substrate and to have tyrosine kinase-modulated guanine-nucleotide-releasing-factor activity. This implies a function in the control of ras or ras-like proteins. Because ras activation has been shown to be a downstream event following stimulation of the interleukin-2 (IL-2) receptor, we investigated the possibility that vav was involved in IL-2 signal transduction pathways, using human T cells as a model. We found rapid tyrosine phosphorylation of vav in response to IL-2 within 1 min, with maximum increase of phosphorylation of 5-fold occurring by 5 min after treatment in normal human T cells. IL-2 stimulation of the human T-cell line YT and a subclone of the YT cell line (YTlck-) that does not express message for the src-family kinase p56lck also results in a rapid rate of tyrosine phosphorylation of vav of more than 5-fold by 5 min. These results suggest that vav may play an important role in IL-2-stimulated signal transduction and that there is not a strict requirement for the tyrosine kinase p56lck.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.