ArticleProceedings of the National Academy of Sciences of the United States of America1993
Zn2+ potentiates excitatory action of ATP on mammalian neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 108 citations in OpenAlex.
- The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors.International journal of Alzheimer's disease · 2011Article
- Structural interpretation of P2X receptor mutagenesis studies on drug action.British journal of pharmacology · 2010Review
- Orthosteric and allosteric binding sites of P2X receptors.European biophysics journal : EBJ · 2009Review
- Opposite effects of zinc on human and rat P2X2 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Pharmacology of P2X channels.Pflugers Archiv : European journal of physiology · 2006Review
- On the contribution of the first transmembrane domain to whole-cell current through an ATP-gated ionotropic P2X receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties.British journal of pharmacology · 2001Article
- Local regulation of [(3)H]-noradrenaline release from the isolated guinea-pig right atrium by P(2X)-receptors located on axon terminals.British journal of pharmacology · 2000Article
- Inhibition by ethanol of rat P2X(4) receptors expressed in Xenopus oocytes.British journal of pharmacology · 2000Article
- Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology.British journal of pharmacology · 1999Article
- A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility method.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Inhibition of ATP-activated current by zinc in dorsal root ganglion neurones of bullfrog.The Journal of physiology · 1997Article
- Modulation by adenosine of GABA-activated current in rat dorsal root ganglion neurons.The Journal of physiology · 1997Article
- Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia.British journal of pharmacology · 1996Article
- Potentiation by cadmium ion of ATP-evoked dopamine release in rat phaeochromocytoma cells.British journal of pharmacology · 1996Article
- Inhibition by Zn2+ of uridine 5'-triphosphate-induced Ca(2+)-influx but not Ca(2+)-mobilization in rat phaeochromocytoma cells.British journal of pharmacology · 1995Article
- An electrophysiological investigation of the properties of a murine recombinant 5-HT3 receptor stably expressed in HEK 293 cells.British journal of pharmacology · 1995Article
- Effects of metal cations on [3H]alpha,beta-methylene ATP binding in rat vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the increasing recognition that ATP is an important extracellular excitatory mediator in the nervous system, the regulation of ATP receptors is poorly understood. Because the extracellular Zn2+ concentration is regulated in a variety of biological tissues, we studied modulation of the ATP-gated cation channel by Zn2+ in mammalian neurons using the whole-cell patch-clamp technique. In approximately 73% of cells tested, the amplitude of ATP-activated membrane ion current increased up to 5-fold in the presence of micromolar concentrations of Zn2+. The characteristics of this action suggest that Zn2+ increases the apparent affinity of the receptor for ATP. In addition, Zn2+ increased membrane depolarization and action potential firing elicited by ATP. These observations suggest that Zn2+ may play a physiological role in regulating the excitatory action of ATP on mammalian neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.