ArticleProceedings of the National Academy of Sciences of the United States of America1993
Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 2 of them syntheses that pooled it.
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Who cites it
145 citing papers in PubMed, 2 syntheses or guidelines pooled it, 527 citations in OpenAlex.
- Pooled it
- A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes.PloS one · 2014Pooled it
- Development necessitates evolutionarily conserved factors.Scientific reports · 2025Article
- Human Genetics of Truncus Arteriosus.Advances in experimental medicine and biology · 2024Review
- Modeling a variant of unknown significance in the Drosophila ortholog of the human cardiogenic gene NKX2.5.Disease models & mechanisms · 2023Article
- The MEF2A transcription factor interactome in cardiomyocytes.Cell death & disease · 2023Article
- Disease-associated non-coding variants alter NKX2-5 DNA-binding affinity.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- Development of a Method for the In Vivo Generation of Allogeneic Hearts in Chimeric Mouse Embryos.International journal of molecular sciences · 2023Article
- Transcriptome studies of congenital heart diseases: identifying current gaps and therapeutic frontiers.Frontiers in genetics · 2023Review
- The mTOR signaling pathway in cardiac aging.The journal of cardiovascular aging · 2023Article
- The opportunities and challenges of usingFrontiers in physiology · 2023Article
- Review
- Modeling congenital heart disease: lessons from mice, hPSC-based models, and organoids.Genes & development · 2022Review
- Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation.Scientific reports · 2021Article
- Nkx2.5 Functions as a Conditional Tumor Suppressor Gene in Colorectal Cancer CellsFrontiers in oncology · 2021Article
- OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.Developmental biology · 2020Article
- The developing heart: fromDevelopment (Cambridge, England) · 2020Review
- Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward KThe journal of physiological sciences : JPS · 2020Article
- Cardiac Pacemaker Cells Generate Cardiomyocytes from Fibroblasts in Long-Term Cultures.Scientific reports · 2019Article
- The LL-100 panel: 100 cell lines for blood cancer studies.Scientific reports · 2019Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular control of the differentiation process depends in part on lineage-restricted transcription factors that regulate expression of tissue-specific genes. Although significant progress has been made in molecular understanding of skeletal muscle differentiation, no information is available concerning the genes involved in development of the heart, the first organ to form in vertebrate embryos. Many vertebrate homeobox-containing genes have been shown to be expressed in broad regions of the mouse embryo, but no expression of a homeobox gene has been found in the most anterior region of the early embryo, the heart primordium. We report here on the cloning of a murine homeobox cDNA, Csx (cardiac-specific homeobox). The Csx homeodomain sequence is divergent from those of the Hox class genes but is related to that of Drosophila msh-2 (NK-4), which plays a key role in Drosophila heart formation. Csx is conserved in evolution and Csx homologs exist in all vertebrates examined. Transcripts of Csx are detected from the presomite stage (7.5 days postcoitum), when mesoderm differentiates into promyocardium. Csx expression is restricted in the myocardial cells from 8.5 days postcoitum through adult. Csx is not expressed in skeletal or smooth muscle or any other tissues examined. Expression of Csx precedes that of cardiac-specific genes in embryonic stem cells differentiating into beating myocardial cells in vitro. Although physiological function of Csx is yet to be determined, the temporal and spacial pattern of Csx expression raises a possibility that Csx may play a critical role in the differentiation of cardiac cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.