ArticleProceedings of the National Academy of Sciences of the United States of America1993
Expression cloning of rat renal Na+/SO4(2-) cotransport.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 152 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Structural basis for the reaction cycle and transport mechanism of human NaScience advances · 2024Article
- Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.Science advances · 2024Article
- SLC26 Anion Transporters.Handbook of experimental pharmacology · 2024Review
- Non-Aquaporin Water Channels.Advances in experimental medicine and biology · 2023Article
- Variants in mycophenolate and CMV antiviral drug pharmacokinetic and pharmacodynamic genes and leukopenia in heart transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Na+-sulfate cotransporter SLC13A1.Pflugers Archiv : European journal of physiology · 2014Review
- The Role of INDY in Metabolic Regulation.Computational and structural biotechnology journal · 2013Review
- Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier.Frontiers in pharmacology · 2012Article
- Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis.Biochimica et biophysica acta · 2009Article
- Functional reconstitution of SdcS, a Na+-coupled dicarboxylate carrier protein from Staphylococcus aureus.Journal of bacteriology · 2007Article
- Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1.Biochemistry · 2006Article
- Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters.Pflugers Archiv : European journal of physiology · 2006Review
- Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus.Journal of bacteriology · 2005Article
- The rat Na+-sulfate cotransporter rNaS2: functional characterization, tissue distribution, and gene (slc13a4) structure.Pflugers Archiv : European journal of physiology · 2005Article
- Characterization of the human renal Na(+)-sulphate cotransporter gene ( NAS1) promoter.Pflugers Archiv : European journal of physiology · 2004Article
- The SLC13 gene family of sodium sulphate/carboxylate cotransporters.Pflugers Archiv : European journal of physiology · 2004Review
- Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Transport of toxic metals by molecular mimicry.Environmental health perspectives · 2002Review
- Role of cationic amino acids in the Na+/dicarboxylate co-transporter NaDC-1.The Biochemical journal · 2000Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injection of rat kidney cortex mRNA into Xenopus laevis oocytes leads to a stimulation of Na(+)-dependent SO4(2-) uptake. Based on this information, we have isolated from a corresponding library a cDNA (NaSi-1) that is most likely related to a Na+/SO4(2-) cotransport system. NaSi-1 cRNA leads in a time- and dose-dependent manner to specific stimulation of Na(+)-dependent SO4(2-) uptake in oocytes. The apparent affinity constants of the NaSi-1 cRNA-expressed transport resemble those of Na+/SO4(2-) cotransport in brush-border membrane. The NaSi-1 cDNA contains 2239 bp [including a poly(A) tail] and encodes a protein of 595 amino acids (66.05 kDa); the hydropathy profile suggests at least eight membrane-spanning regions. In vitro translation of NaSi-1 cRNA results in a protein of the expected size and suggests glycosylation. Northern blot analysis shows signals of 2.3 and 2.9 kb in kidney (more abundant in cortex than in papilla/medulla) and in mucosa of small intestine of rats. The above data indicate that we have structurally identified a membrane protein involved in renal and small-intestinal brush-border membrane Na+/SO4(2-) cotransport.
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